One-Pot Synthesis of 4-Substituted 1H-[1,2,3]triazolo[4,5-c]quinolines Through CuO-Promoted Tandem Cyclization Reactions of (E)-3-(2-Bromoaryl)-1-arylprop-2-en-1-ones with Sodium Azide

被引：13
|
作者：
Li, Kangning [1 ,2 ]
Chen, Jinying [1 ,2 ]
Li, Jihui [1 ,2 ]
Chen, Yongxin [1 ,2 ]
Qu, Jinpeng [1 ,2 ]
Guo, Xin [1 ,2 ]
Chen, Chunxia [1 ,2 ]
Chen, Baohua [1 ,2 ]
机构：
[1] Lanzhou Univ, State Key Lab Organ Chem, Lanzhou 730000, Peoples R China
[2] Key Lab Nonferrous Met Chem & Resources Utilizat, Lanzhou 730000, Peoples R China
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2013年 / 2013卷 / 28期
基金：
美国国家科学基金会;
关键词：
Domino reactions; Nitrogen heterocycles; Copper; Azides; Cyclization; TERMINAL ACETYLENES; CLICK CHEMISTRY; ACID-CHLORIDES; CYCLOADDITION; 1,2,3-TRIAZOLES; DERIVATIVES; INHIBITORS; AMINATION; QUINOLINE;
D O I：
10.1002/ejoc.201300924
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A facile and efficient protocol for the synthesis of 4-substituted-1H-[1,2,3]triazolo[4,5-c]quinolines through a CuO-promoted tandem cyclization reaction has been developed. This method allows for the construction of two heterocyclic rings in a one-pot reaction of readily available (E)-3-(2-bromoaryl)-1-arylprop-2-en-1-ones and sodium azide without the addition of any additive. A series of triazole-fused N-heterocyclic compounds could be prepared in moderate to good yields.
引用
收藏
页码：6246 / 6248
页数：3
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