Inhibition of sebum production and Propionibacterium acnes lipase activity by fullerenol, a novel polyhydroxylated fullerene: Potential as a therapeutic reagent for acne

被引：0

作者：

Inui, Shigeki ^{[1
]}

Aoshima, Hisae ^{[2
]}

Ito, Masayuki ^{[2
]}

Kokubo, Ken ^{[3
]}

Itami, Satoshi ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Med, Dept Regenerat Dermatol, Suita, Osaka 5650871, Japan

[2] Vitamin C60 BioRes Corp, Tokyo 1030028, Japan

[3] Osaka Univ, Grad Sch Engn, Div Appl Chem, Suita, Osaka 5650871, Japan

来源：

JOURNAL OF COSMETIC SCIENCE | 2012年 / 63卷 / 04期

关键词：

D O I：

暂无

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Oxidative stress plays a major role in acne formation; this suggests that oxygen-radical scavengers could be potential therapeutic agents. Fullerenol C-60(OH)(44), a recently developed polyhydroxylated fullerene, is a spherical carbon molecule that has many hydroxyl groups capable of potent radical-scavenging activity. We have investigated its inhibitory effects in vitro on sebum production in hamster sebocytes and in Propionibacterium acnes lipase activity. Sebum production was significantly reduced by 1.5 mu M of fullerenol in cells that had been irradiated with 10 mJ/cm(2) UVB, although it was not altered in the non-irradiated cells, indicating that fullerene is a sebum suppressor for sebocytes under oxidative stress, such as that induced by UVB. It was also found that fullerenol has inhibitory activity against P. acnes lipase. These results suggest that fullerenol could be a beneficial skin care reagent for controlling acne vulgaris by suppressing sebum in the inflammatory response and by reducing P. acnes lipase activity.

引用

页码：259 / 265

页数：7