Inferring the regulatory network behind a gene expression experiment

被引：8
|
作者：
Bleda, Marta [1 ,2 ]
Medina, Ignacio [1 ]
Alonso, Roberto [1 ]
De Maria, Alejandro [1 ]
Salavert, Francisco [1 ,2 ]
Dopazo, Joaquin [1 ,2 ,3 ]
机构：
[1] CIPF, Dept Bioinformat & Genom, Valencia, Spain
[2] CIBERER, Valencia 46012, Spain
[3] CIPF, Funct Genom Node INB, Valencia 46012, Spain
来源：
NUCLEIC ACIDS RESEARCH | 2012年 / 40卷 / W1期
关键词：
WEB TOOL; GENOMIC DATA; MICRORNA; KNOWLEDGEBASE; ANNOTATION; SEQUENCES; TARGETS; MOTIFS;
D O I：
10.1093/nar/gks573
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Transcription factors (TFs) and miRNAs are the most important dynamic regulators in the control of gene expression in multicellular organisms. These regulatory elements play crucial roles in development, cell cycling and cell signaling, and they have also been associated with many diseases. The Regulatory Network Analysis Tool (RENATO) web server makes the exploration of regulatory networks easy, enabling a better understanding of functional modularity and network integrity under specific perturbations. RENATO is suitable for the analysis of the result of expression profiling experiments. The program analyses lists of genes and search for the regulators compatible with its activation or deactivation. Tests of single enrichment or gene set enrichment allow the selection of the subset of TFs or miRNAs significantly involved in the regulation of the query genes. RENATO also offers an interactive advanced graphical interface that allows exploring the regulatory network found.RENATO is available at: nhttp://renato.bioinfo.cipf.es/.
引用
收藏
页码：W168 / W172
页数：5
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