Choline chloride and lactic acid: A natural deep eutectic solvent for one-pot rapid construction of spiro[indoline-3,4′-pyrazolo[3,4-b]pyridines]

被引：90
|
作者：
Zhang, Wei-Hong [1 ]
Chen, Meng-Nan [1 ]
Hao, Yi [1 ]
Jiang, Xin [1 ]
Zhou, Xiao-Lin [1 ]
Zhang, Zhan-Hui [1 ]
机构：
[1] Hebei Normal Univ, Hebei Key Lab Organ Funct Molecules, Natl Demonstrat Ctr Expt Chem Educ, Coll Chem & Mat Sci, Shijiazhuang 050024, Hebei, Peoples R China
来源：
JOURNAL OF MOLECULAR LIQUIDS | 2019年 / 278卷
基金：
中国国家自然科学基金;
关键词：
Natural deep eutectic solvents; Choline chloride/lactic acid; Multicomponent reaction; Isatin; Spirooxindoles; Pyrazolo[3,4-b]quinoline; RECYCLABLE HETEROGENEOUS CATALYST; 3-COMPONENT SYNTHESIS; EFFICIENT SYNTHESIS; DUAL SOLVENT/CATALYST; IONIC LIQUIDS; DERIVATIVES; SPIROOXINDOLES; MIXTURE; DIHYDRATE; GREEN;
D O I：
10.1016/j.molliq.2019.01.065
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The application of natural eutectic solvent (NDDES) in organic synthesis has received more and more attention. In this work, a green protocol for one-pot synthesis of spiro[indoline-3,4'-pyrazolo[3,4-b]pyridines] via three-component reactions of 1H-pyrazol-5-amin, isatin and enolizable C-H activated compound is achieved by the combination of microwave irradiation with choline chloride and lactic acid based NDDES. This novel method is clean, cheap, simple, high yield, chromatography-free and scalable. The use of choline chloride and lactic acid as a biodegradable, recycled and reusable media meets most of the criteria to be considered as a sustainable and environmentally benign process. (C) 2019 Elsevier B.V. All rights reserved.
引用
收藏
页码：124 / 129
页数：6
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