Enantioseparation with a chiral micro-HPLC system

被引：0
|
作者：
Zhu Zhi-Jia [1 ]
Wang Qian-Qian [1 ]
Kang Jing-Wu [2 ]
机构：
[1] Donghua Univ, Coll Chem & Chem Engn & Biotechnol, Shanghai 201620, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China
来源：
ACTA CHIMICA SINICA | 2008年 / 66卷 / 15期
关键词：
micro-column HPLC; cellulose tris(3,5-dimethylphenylcarbamate); enantioseparation;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The present paper describes the protocol for the preparation of a home made chiral micro-HPLC system and the chiral packing material with cellulose-based chiral stationary phase. The column packing technique was investigated and the key factors which may influence the performance of the chiral separation system were evaluated with several chiral compounds. The composition of the mobile phase and its flow rate were optimized. Finally, five enantiomers were Successfully separated. It was illustrated that the system was characterized by simplicity, high resolution, low Consumption of the mobile phase and high speed. The system could be easily prepared at the laboratory for enantioseparation.
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页码：1845 / 1849
页数：5
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