Anti-Inflammatory Activity of Heterocarpin from the Salt Marsh Plant Corydalis heterocarpa in LPS-Induced RAW 264.7 Macrophage Cells

被引：17
|
作者：
Kim, You Ah [1 ]
Kong, Chang-Suk [2 ]
Park, Hyo Hyun [3 ]
Lee, Eunkyung [3 ]
Jang, Mi-Soon [4 ]
Nam, Ki-Ho [4 ]
Seo, Youngwan [1 ,5 ]
机构：
[1] Korea Maritime & Ocean Univ, Div Marine Biosci, Busan 606791, South Korea
[2] Silla Univ, Dept Food & Nutr, Busan 617736, South Korea
[3] Korea Promot Inst Tradit Med Ind, Div Res & Dev, Gyongsan 712260, South Korea
[4] Natl Fisheries Res & Dev Inst, Food & Safety Res Ctr, Busan 619705, South Korea
[5] Korea Maritime & Ocean Univ, Ocean Sci & Technol Sch, Busan 606791, South Korea
来源：
MOLECULES | 2015年 / 20卷 / 08期
基金：
新加坡国家研究基金会;
关键词：
Corydalis heterocarpa; heterocarpin; furochromone; anti-inflammatory effect; NITRIC-OXIDE; PATHOPHYSIOLOGY; GLYCOSIDES; CYTOKINES; ALKALOIDS; RESPONSES; COUMARINS;
D O I：
10.3390/molecules200814474
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The inhibitory effect of three chromones 1-3 and two coumarins 4-5 on the production of nitric oxide (NO) was evaluated in LPS-induced RAW 264.7 macrophage cells. Among the compounds tested heterocarpin (1), a furochromone, significantly inhibited its production in a dose-dependent manner. In addition, heterocarpin suppressed prostaglandin E-2 (PGE(2)) production and expression of cytokines such as inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor- (TNF-), interleukin-1 (IL-1) and interleukin-6 (IL-6).
引用
收藏
页码：14474 / 14486
页数：13
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