Cell cycle activation in striatal neurons from Huntington's disease patients and rats treated with 3-nitropropionic acid

被引：72

作者：

Pelegri, Carme ^{[1
]}

Duran-Vilaregut, Joaquim ^{[1
]}

del Valle, Jaume ^{[1
]}

Crespo-Biel, Natalia ^{[2
]}

Ferrer, Isidre ^{[3
]}

Pallas, Merce ^{[2
]}

Camins, Antoni ^{[2
]}

Vilaplana, Jordi ^{[1
]}

机构：

[1] Univ Barcelona, Dept Fisiol, Fac Farm, E-08028 Barcelona, Spain

[2] Univ Barcelona, Unitat Farmacol & Farmacogoniosia, Fac Farm, Inst Biomed, E-08028 Barcelona, Spain

[3] Univ Barcelona, Inst Neuropatol, IDIBELL, Hosp Univ Bellvitge,Hosp Llobregat, E-08007 Barcelona, Spain

来源：

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE | 2008年 / 26卷 / 07期

关键词：

Huntington's disease; Apoptosis; Cell cycle; Striatum;

D O I：

10.1016/j.ijdevneu.2008.07.016

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

This study was undertaken to investigate the potential role of cell cycle re-entry in an experimental model of Huntington's disease and in human brain samples. We found that after treatment of rats with the mitochondrial neurotoxin 3-nitropropionic acid, the expression of cell cycle markers of G I phase measured by immunohistochemistry was induced in the striatal brain region. Furthermore, we detected an increase in the nuclear and also cytoplasmatic E2F-1 expression, suggesting that this protein could activate the apoptotic cascade in rat brain. Western blot analysis of post-mortem brain samples from patients also showed an increase in the expression of E2F-1 and cyclin D1 in comparison with control samples. These results indicate that cell cycle re-entry is activated in Huntington's disease and may contribute to the neurodegenerative process. (C) 2008 ISDN. Published by Elsevier Ltd. All rights reserved.

引用

页码：665 / 671

页数：7

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