Positively Charged Silver Nanoparticles as Labels for Paper-Based Colorimetric Detection of Heparin

被引：3
|
作者：
Kumar, Sanjay [1 ]
Bhushan, Pulak [1 ]
Bhattacharya, Shantanu [1 ,2 ]
机构：
[1] Indian Inst Technol Kanpur, Dept Mech Engn, Microsyst Fabricat Lab, Kanpur, Uttar Pradesh, India
[2] Indian Inst Technol Kanpur, Design Programme, Kanpur, Uttar Pradesh, India
来源：
2ND INTERNATIONAL CONFERENCE FOR INNOVATION IN BIOMEDICAL ENGINEERING AND LIFE SCIENCES | 2018年 / 67卷
关键词：
Colorimetric detection; Heparin; (+) AgNPs; Paper-based detection; SENSITIVITY;
D O I：
10.1007/978-981-10-7554-4_41
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
A novel paper-based colorimetric sensor has been developed for ultrasensitive detection of heparin based on aggregation of positively charged silver nanoparticles. The electrostatic interaction between negatively charged heparin and positively charged silver nanoparticles (AgNPs) resulted in a shift in the surface plasmon resonance (SPR) wavelength leading to a color change from yellow to colorless. The proposed assay can selectively detect heparin with an ultra-low detection limit of 1.898 ng mL(-1) in solution and 8.68 mu g mL(-1) on paper. In future, the assay can be further employed for detection of heparin in human blood serum samples.
引用
收藏
页码：235 / 240
页数：6
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