Life-Threatening Hemolytic Anemia after Intrapleural Instillation of OK-432 for Treatment of Congenital Chylothorax

被引：6
|
作者：
Sze, Steve W. P. [1 ]
Ng, Pak C. [1 ]
Lam, Hugh S. [1 ]
机构：
[1] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Paediat, Hong Kong, Hong Kong, Peoples R China
来源：
NEONATOLOGY | 2016年 / 110卷 / 04期
关键词：
Congenital chylothorax; Hemolysis; Infants; OK-432; THERAPY;
D O I：
10.1159/000447286
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Recent reports have advocated treatment of congenital chylothorax with chemical pleurodesis via intrapleural administration of OK-432. Severe complications have not been reported, but recently we have encountered a life-threatening case of massive hemolysis after the procedure. The hemoglobin of the infant decreased from 8.7 to 3.1 g/dl within 48 h, with concomitant severe hyperbilirubinemia (472 mu mol/l) requiring exchange transfusion. Frontline neonatologists should be aware of this rare but potentially life-threatening adverse reaction. In addition, it is possible that a longer indwelling time (3.5 vs. 0.5 h) for OK-432 pleurodesis may alter the therapeutic response. (C) 2016 S. Karger AG, Basel
引用
收藏
页码：303 / 306
页数：4
相关论文
共 50 条
  • [1] A case of successful fetal therapy for congenital chylothorax by intrapleural injection of OK-432
    Tanemura, M
    Nishikawa, N
    Kojima, K
    Suzuki, Y
    Suzumori, K
    ULTRASOUND IN OBSTETRICS & GYNECOLOGY, 2001, 18 (04) : 371 - 375
  • [2] Intrapleural injection of OK-432 as the primary in-utero treatment for fetal chylothorax
    Leung, Viola K. T.
    Suen, Stephen S. H.
    Ting, Y. H.
    Law, L. W.
    Lau, T. K.
    Leung, T. Y.
    HONG KONG MEDICAL JOURNAL, 2012, 18 (02) : 156 - 159
  • [3] Treatment of severe fetal chylothorax associated with pronounced hydrops with intrapleural injection of OK-432
    Jorgensen, C
    Brocks, V
    Bang, J
    Jorgensen, FS
    Ronsbro, L
    ULTRASOUND IN OBSTETRICS & GYNECOLOGY, 2003, 21 (01) : 66 - 69
  • [4] OK-432 CHEMICAL PLEURODESIS FOR THE TREATMENT OF PERSISTENT CHYLOTHORAX
    NAKANO, A
    KATO, M
    WATANABE, T
    KAWAI, N
    OTA, H
    HATTORI, T
    KOBAYASHI, Y
    NIMURA, Y
    HEPATO-GASTROENTEROLOGY, 1994, 41 (06) : 568 - 570
  • [5] TREATMENT OF POSTOPERATIVE CHYLOTHORAX BY PLEURODESIS WITH THE STREPTOCOCCAL PREPARATION OK-432
    SHIMIZU, J
    HAYASHI, Y
    ODA, M
    MORITA, K
    ARANO, Y
    NAGAO, S
    MURAKAMI, S
    URAYAMA, H
    WATANABE, Y
    THORACIC AND CARDIOVASCULAR SURGEON, 1994, 42 (04): : 233 - 236
  • [6] IMMUNE HEMOLYTIC-ANEMIA ASSOCIATED WITH STREPTOCOCCAL PREPARATION OK-432
    NOMURA, S
    KANOH, T
    CANCER, 1987, 59 (08) : 1409 - 1411
  • [7] Antenatal treatment of chylothorax and cystic hygroma with OK-432 in nonimmune hydrops fetalis
    Chen, M
    Chen, CP
    Shih, JC
    Chou, HC
    Yu, CL
    Wang, ET
    Hsieh, CY
    FETAL DIAGNOSIS AND THERAPY, 2005, 20 (04) : 309 - 315
  • [8] Elevation of serum procalcitonin in patients after chemical pleurodesis with intrapleural injection of OK-432
    Xu, Bing-ling
    Yu, Jin-quan
    Tang, Ke-jing
    Liu, Da-yue
    Kuang, Yu-kun
    CLINICAL RESPIRATORY JOURNAL, 2014, 8 (01): : 41 - 44
  • [9] Treatment of microcystic lymphangioma with OK-432 after intralesional excision
    Yabe, Tetsuji
    Takahashi, Makoto
    JOURNAL OF DERMATOLOGY, 2009, 36 (01): : 60 - 62
  • [10] Successful Treatment of Severe Fetal Chylothorax Resistant to Repeated Pleuroamniotic Shunting by OK-432 Pleurodesis
    Lo, T. K.
    Lau, W. L.
    Lam, Y. Y.
    Tang, M. H. Y.
    Leung, T. Y.
    Leung, W. C.
    FETAL DIAGNOSIS AND THERAPY, 2012, 31 (04) : 260 - 263
12345