Antibody-drug conjugates with DNA inhibitor linker-payloads can overcome resistance in cultured tumor cells made resistant to conjugates with cleavable-linked auristatins

被引：0

作者：

Tan, Xingzhi ^{[1
]}

Sung, Matthew ^{[1
]}

Loganzo, Frank ^{[1
]}

机构：

[1] Pfizer Inc, Pearl River, NY USA

来源：

CANCER RESEARCH | 2018年 / 78卷 / 13期

关键词：

D O I：

10.1158/1538-7445.AM2018-1978

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

1978

引用

页数：2

共 10 条

[1] Antibody-drug conjugates with modified linker-payloads overcome resistance to a trastuzumab-maytansinoid conjugate in multiple cultured tumor cell models
Tan, Xingzhi
Lu, Bingwen
Jin, Guixian
Wang, Fang
Myers, Jeremy
Musto, Sylvia
Lam, My-Hanh
Hu, William
Khandke, Kiran
Arndt, Kim
Gerber, Hans-Peter
Loganzo, Frank
CANCER RESEARCH, 2014, 74 (19)
[2] Chemical Modification of Linkers Provides Stable Linker-Payloads for the Generation of Antibody-Drug Conjugates
Poudel, Yam B.
Chowdari, Naidu S.
Cheng, Heng
Iwuagwu, Christiana I.
King, H. Dalton
Kotapati, Srikanth
Passmore, David
Rampulla, Richard
Mathur, Arvind
Vite, Gregory
Gangwar, Sanjeev
ACS MEDICINAL CHEMISTRY LETTERS, 2020, 11 (11): : 2190 - 2194
[3] Antibody-drug conjugates with dual payloads for combating breast tumor heterogeneity and drug resistance
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Aiko Yamaguchi
Yasuaki Anami
Wei Xiong
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Zhiqiang An
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[4] Antibody-drug conjugates with dual payloads for combating breast tumor heterogeneity and drug resistance
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Yamaguchi, Aiko
Anami, Yasuaki
Xiong, Wei
Otani, Yoshihiro
Lee, Jangsoon
Ueno, Naoto T.
Zhang, Ningyan
An, Zhiqiang
Tsuchikama, Kyoji
NATURE COMMUNICATIONS, 2021, 12 (01)
[5] Uptake of antibody-drug conjugates by cultured Kupffer cells can predict pharmacokinetics
Meyer, David
Shum, Sara
Jonas, Mechthild
Anderson, Martha
Hunter, Joshua
Chemuturi, Nagendra
Okeley, Nicole
Lyon, Robert
CANCER RESEARCH, 2016, 76
[6] Antibody-Drug Conjugates with Indolinobenzodiazepine Dimer Payloads: DNA-Binding Mechanism of indolinobenzodiazepine Dimer Catabolites in Target Cancer Cells
Singh, Rajeeva
Reid, Emily E.
Harris, Luke
Salomon, Paulin L.
Miller, Michael L.
Chari, Ravi V. J.
Keating, Thomas A.
MOLECULAR PHARMACEUTICS, 2020, 17 (01) : 50 - 58
[7] Antibody-drug conjugates (ADCs) with indolinobenzodiazepine dimer (IGN) payloads: DNA-binding mechanism of IGN catabolites in target cancer cells
Singh, Rajeeva
Harris, Luke
Salomon, Paulin
Reid, Emily E.
Miller, Michael L.
Chari, Ravi V.
Keating, Thomas A.
CANCER RESEARCH, 2019, 79 (13)
[8] Potent antigen-specific anti-tumor activity observed with antibody-drug conjugates (ADCs) made using a new class of DNA-crosslinking agents
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Mayo, Michele
Jones, Gregory
Reid, Emily
Archer, Katie
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Pinkas, Jan
Singh, Rajeeva
Chari, Ravi
MOLECULAR CANCER THERAPEUTICS, 2009, 8 (12)
[9] Antibody-drug conjugates (ADCs) of peptide-linked Indolino-Benzodiazepine (IGN) DNA-alkylator provides improved anti-tumor activity over that of a crosslinker
Miller, Michael L.
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Ponte, Jose F.
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Reid, Emily E.
Archer, Katie E.
Wu, Rui
Maloney, Erin K.
Ab, Olga
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CANCER RESEARCH, 2017, 77
[10] Antibody-drug conjugates (ADCs) with tubulysin and PBD warheads, maintain potent in vitro cytotoxicity against multidrug-resistant tumor cells expressing P-glycoprotein (P-gp)
Mao, Shenlan
Fleming, Ryan
Bezabeh, Binyam
Dimasi, Nazzareno
Toader, Dorin
Cailleau, Thais
Howard, Philip
Gao, Changshou
Hollingsworth, Bob
Kamal, Adeela
Harper, Jay
CANCER RESEARCH, 2015, 75

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