Breast cancer precursors: diagnostic issues and current understanding on their pathogenesis

被引：5

作者：

Pare, Rahmawati ^{[1
,2
]}

Yang, Tao ^{[1
,2
,3
]}

Shin, Joo-Shik ^{[1
,2
,3
]}

Tan, Puay Hoon ^{[6
]}

Lee, C. Soon ^{[1
,2
,3
,4
,5
]}

机构：

[1] Univ Western Sydney, Sch Med, Discipline Pathol, Sydney, NSW, Australia

[2] Ingham Inst Appl Med Res, Canc Pathol & Cell Biol Lab, Sydney, NSW, Australia

[3] Liverpool Hosp, Sydney South West Area, Dept Anat Pathol, Pathol Serv, Sydney, NSW, Australia

[4] Royal Prince Alfred Hosp, Sydney South West Area, Dept Tissue Pathol & Diagnost Oncol, Pathol Serv, Sydney, NSW, Australia

[5] Univ Sydney, Bosch Inst, Sydney, NSW 2006, Australia

[6] Singapore Gen Hosp, Dept Pathol, Singapore, Singapore

来源：

PATHOLOGY | 2013年 / 45卷 / 03期

关键词：

ADH; atypical ductal hyperplasia; breast cancer; DCIS; ductal carcinoma in situ; LCIS; lobular carcinoma in situ; CARCINOMA IN-SITU; COLUMNAR CELL LESIONS; COMPARATIVE GENOMIC HYBRIDIZATION; INTRADUCTAL PROLIFERATIVE LESIONS; DUCTAL CARCINOMA; LOBULAR NEOPLASIA; ALLELE IMBALANCE; PROGRESSION; HYPERPLASIA; DISTINCT;

D O I：

10.1097/PAT.0b013e32835f2249

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

The development of breast malignancy has been recognised to progress through a number of morphological precursor lesions. More recently, specific molecular alterations have been recognised in these precursor lesions. These changes appear to determine a specific malignant phenotype, which in turn, may realign the current opinion on the classification of breast cancer along molecular characteristics. This review will highlight the morphological features of these precursor lesions and their relationship to the complex molecular processes involved in their development.

引用

页码：209 / 213

页数：5

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