Unveiling Latent α-Iminocarbene Reactivity for Intermolecular Cascade Reactions through Alkyne Oxidative Amination

被引：44
|
作者：
Mace, Nina [1 ]
Thornton, Aaron R. [1 ]
Blakey, Simon B. [1 ]
机构：
[1] Emory Univ, Dept Chem, Atlanta, GA 30322 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 22期
基金：
美国国家科学基金会;
关键词：
alkynes; carbenoids; heterocycles; rhodium; synthetic methods; C-H AMINATION; RHODIUM(II) AZAVINYL CARBENES; HIGHLY SUBSTITUTED PYRROLES; DIAZO OXIME ETHERS; DIASTEREOSELECTIVE SYNTHESIS; STEREOTRIADS; AZIDES; AMINOCYCLOPROPANES; FUNCTIONALIZATION; ALLOSECURININE;
D O I：
10.1002/anie.201301087
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Setting a trap: Described is the development of a metallonitrene-initiated alkyne oxidation cascade with intermolecular trapping of the reactive intermediate with a variety of allyl ethers to provide α-oxyimine products in which new Cï£N, C-O, and C-C bonds have all been generated (see Scheme; tfacam=trifluoroacetamide). Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：5836 / 5839
页数：4
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