Is kinetoplastid pan-editing the result of an evolutionary balancing act?
被引:26
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作者:
Speijer, D
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Univ Amsterdam, Acad Med Ctr, Dept Med Biochem, NL-1105 AZ Amsterdam, NetherlandsUniv Amsterdam, Acad Med Ctr, Dept Med Biochem, NL-1105 AZ Amsterdam, Netherlands
Speijer, D
[1
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机构:
[1] Univ Amsterdam, Acad Med Ctr, Dept Med Biochem, NL-1105 AZ Amsterdam, Netherlands
Kinetoplastid U-insertion/deletion type editing is a highly elaborate process to generate translationally competent mitochondrial mRNAs. All evolutionary models to explain its origin and extent in present day organisms lack a convincing description of the advantage(s) responsible for an active increase of the editing potential. This advantage can be found in the gene fragmentation that is inherent in pan-editing which gives protection against loss of temporarily non expressed mitochondrial genes during periods of intense intraspecies competition.