Is kinetoplastid pan-editing the result of an evolutionary balancing act?

被引:26
|
作者
Speijer, D [1 ]
机构
[1] Univ Amsterdam, Acad Med Ctr, Dept Med Biochem, NL-1105 AZ Amsterdam, Netherlands
关键词
kinetoplastid RNA (pan)-editing; trypanosomatids; mitochondria;
D O I
10.1080/15216540600551355
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Kinetoplastid U-insertion/deletion type editing is a highly elaborate process to generate translationally competent mitochondrial mRNAs. All evolutionary models to explain its origin and extent in present day organisms lack a convincing description of the advantage(s) responsible for an active increase of the editing potential. This advantage can be found in the gene fragmentation that is inherent in pan-editing which gives protection against loss of temporarily non expressed mitochondrial genes during periods of intense intraspecies competition.
引用
收藏
页码:91 / 96
页数:6
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