Design and synthesis of a peptide that binds specific DNA sequences through simultaneous interaction in the major and in the minor groove

被引：0
|
作者：
Vázquez, ME
Caamaño, AM
Martínez-Costas, J
Castedo, L
Mascareñas, JL [1 ]
机构：
[1] Univ Santiago de Compostela, Dept Quim Organ, Santiago De Compostela 15782, Spain
[2] Univ Santiago de Compostela, Unidad Asociada, CSIC, Santiago De Compostela 15782, Spain
[3] Univ Santiago de Compostela, Dept Bioquim & Biol Mol, Santiago De Compostela 15782, Spain
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2001年 / 40卷 / 24期
关键词：
antibiotics; DNA recognition; peptides;
D O I：
10.1002/1521-3773(20011217)40:24<4723::AID-ANIE4723>3.0.CO;2-L
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A bivalent system capable of binding to hybrid DNA sites through simultaneous interaction in the major and the minor groove (see schematic representation) is formed by appropriate linking of the basic region of a b-ZIP protein (GCN4) to a tripyrrole related to the antibiotic distamycin.
引用
收藏
页码：4723 / +
页数：4
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