Synthesis, crystal structures, and anti-drug-resistant Staphylococcus aureus activities of novel 4-hydroxycoumarin derivatives

被引：30
|
作者：
Li, Ming-kai [1 ]
Li, Jing [2 ]
Liu, Bao-hui [3 ]
Zhou, Ying [1 ]
Li, Xia [4 ]
Xue, Xiao-yan [1 ]
Hou, Zheng [1 ]
Luo, Xiao-xing [1 ]
机构：
[1] Fourth Mil Med Univ, Dept Pharmacol, Sch Pharm, Xian 710032, Peoples R China
[2] Xian Univ Arts & Sci, Sch Chem & Chem Engn, Xian, Peoples R China
[3] Fourth Mil Med Univ, Dept Cardiac Surg, Xijing Hosp, Xian 710032, Peoples R China
[4] Fourth Mil Med Univ, Dept Neurosurg, Xijing Hosp, Xian 710032, Peoples R China
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 2013年 / 721卷 / 1-3期
基金：
中国国家自然科学基金;
关键词：
4-Hydroxycoumarin; Single crystal; Staphylococcus aureus; Minimum inhibitory concentration; COMMUNITY; SUSCEPTIBILITY; BISCOUMARIN; HOSPITALS; OUTBREAK;
D O I：
10.1016/j.ejphar.2013.09.040
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Four novel 4-hydroxycoumarin derivatives (4-MBH, 3-MBH, 4-MDT and 3-MDT) were successfully synthesized and their structures were verified by single-crystal X-ray crystallography. All target compounds were evaluated for their in vitro antibacterial activity against Staphylococcus aureus (S. aureus ATCC 29213), methicillin-resistant S. aureus (MRSA XJ 75302), vancomycin-intermediate S. aureus (Mu50 ATCC 700699), and USA 300 (Los Angeles County clone, LAC). The minimum inhibitory concentration and time-kill curves were obtained for the test compounds and antibiotics. Among the tested compounds, 3-MBH showed the most potent antibacterial activities. (C) 2013 Elsevier B.V. All rights reserved,
引用
收藏
页码：151 / 157
页数：7
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