Role of biomarkers in predicting diabetes complications with special reference to diabetic foot ulcers

被引:22
|
作者
Pichu, Sivakamasundari [1 ,2 ]
Patel, Bhoomika M. [3 ]
Apparsundaram, Subbu [1 ]
Goyal, Ramesh K. [1 ,4 ]
机构
[1] Sri Ramachandra Univ, Clinbio Labs P Ltd 5, Chennai, Tamil Nadu, India
[2] Anna Univ MIT Campus, AU KBC, Chennai 44, Tamil Nadu, India
[3] Nirma Univ, Inst Pharm, Ahmadabad 382481, Gujarat, India
[4] Delhi Pharmaceut Sci & Res Univ, Delhi 110017, India
关键词
biomarkers; diabetes; diabetic complications; foot ulcers; genomics; infections; miRNA; neuropathy; proteomics; wound healing; SMOOTH-MUSCLE-CELLS; EXTRACELLULAR-MATRIX; GENE-EXPRESSION; CHRONIC WOUNDS; MICRORNAS; LEAD; CARDIOMYOPATHY; PATHOGENESIS; CONTRIBUTE; STRESS;
D O I
10.2217/bmm-2016-0205
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Diabetic foot ulcer (DFU) is one of the major complications of diabetes and about 1% of people with diabetes have to go for lower limb amputation. With better understanding of the pathological basis of DFU, number of biomarkers like atrial natriuretic peptides, galectin-3, and cardiac troponins for diabetic cardiomyopathy, cystatin C for diabetics nephropathy and C-reactive protein for infection and procalcitonin could aid in early and noninvasive diagnosis especially when clinical signs are misleading. Predictive role of novel biomarkers in primary prevention however, requires additional studies considering sex, age and multiple complications in DFU. The current review provides an insight about the novel and emerging biomarkers of diabetes and its complications with special reference to DFUs.
引用
收藏
页码:377 / 388
页数:12
相关论文
共 50 条
  • [1] The Bacteriology of Diabetic Foot Ulcers, with a Special Reference to Multidrug Resistant Strains
    Shanmugam, Priyadarshini
    Jeya, M.
    Susan, Linda S.
    JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2013, 7 (03) : 441 - 445
  • [2] The development and complications of diabetic foot ulcers
    Laing, P
    AMERICAN JOURNAL OF SURGERY, 1998, 176 (2A): : 11S - 19S
  • [3] Foot ulcers and their association with diabetic Charcot foot complications
    Rahman, Nabilah Abdul
    Fauzi, Aishah Ahmad
    Chung, Tze Yang
    Latif, Lydia Abdul
    Chan, Soo Chin
    AUSTRALIAN JOURNAL OF GENERAL PRACTICE, 2020, 49 (1-2) : 48 - 53
  • [4] Association of diabetic foot ulcers with chronic vascular diabetic complications in patients with type 2 diabetes
    Megallaa, Magdy H.
    Ismail, Azza A.
    Zeitoun, Mohammed H.
    Khalifa, Mai S.
    DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS, 2019, 13 (02) : 1287 - 1292
  • [5] The Potential Role of Presepsin in Predicting Severe Infection in Patients with Diabetic Foot Ulcers
    Ha, Eun Yeong
    Park, Il Rae
    Chung, Seung Min
    Roh, Young Nam
    Park, Chul Hyun
    Kim, Tae-Gon
    Kim, Woong
    Moon, Jun Sung
    JOURNAL OF CLINICAL MEDICINE, 2024, 13 (08)
  • [6] The Role of Early Revascularization and Biomarkers in the Management of Diabetic Foot Ulcers: A Single Center Experience
    Dinoto, Ettore
    Ferlito, Francesca
    La Marca, Manfredi Agostino
    Tortomasi, Graziella
    Urso, Francesca
    Evola, Salvatore
    Guercio, Giovanni
    Marciano, Marco
    Pakeliani, David
    Bajardi, Guido
    Pecoraro, Felice
    DIAGNOSTICS, 2022, 12 (02)
  • [7] Complications of diabetes: screening for retinopathy and management of foot ulcers
    Melville, A
    Richardson, R
    McIntosh, A
    O'Keeffe, C
    Mason, J
    Peters, J
    Hutchinson, A
    QUALITY IN HEALTH CARE, 2000, 9 (02): : 137 - 141
  • [8] Role of ceramides in diabetic foot ulcers (Review)
    Wang, Ying
    Sun, Zhen
    Zang, Guangyao
    Zhang, Lili
    Wang, Zhongqun
    INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2023, 51 (03)
  • [9] Wound treatment in diabetes patients and diabetic foot ulcers
    Riedel, U.
    Schuessler, E.
    Haertel, D.
    Keiler, A.
    Nestoris, S.
    Stege, H.
    HAUTARZT, 2020, 71 (11): : 835 - 842
  • [10] Diabetes and Diabetic Foot Ulcers: An often hidden problem
    Green, Bronwyn
    Zoepke, Andy
    SOUTH AFRICAN FAMILY PRACTICE, 2013, 55 (06) : 515 - 518