Pyoderma gangrenosum in association with Janus kinase 2 (JAK2V617F) mutation

被引：27
|
作者：
Palanivel, J. A. [1 ]
Macbeth, A. E. [1 ]
Levell, N. J. [1 ]
机构：
[1] Norfolk & Norwich Univ Hosp & NHS Trust, Dept Dermatol, Norwich, Norfolk, England
来源：
CLINICAL AND EXPERIMENTAL DERMATOLOGY | 2013年 / 38卷 / 01期
关键词：
PATHWAY;
D O I：
10.1111/j.1365-2230.2012.04375.x
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Pyoderma gangrenosum (PG) commonly occurs in association with various haematological and inflammatory disorders. We report a new association, a Janus kinase (JAK)2 mutation, in a 63-year-old patient with PG. We hypothesise that PG occurs by direct activation of JAK along with signal transducers and activators of transcription (STAT), a common mechanism involved in the pathogenesis of inflammatory and haematological diseases.
引用
收藏
页码：44 / 46
页数：3
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