Update of Metal-Based Drugs : Problems and Approaches for Solution

被引：0
|
作者：
Huang Meiling [1 ]
Wu Yaling [1 ]
Zhao Pan [1 ]
Yang Xiaoda [1 ]
机构：
[1] Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100191, Peoples R China
来源：
PROGRESS IN CHEMISTRY | 2013年 / 25卷 / 04期
关键词：
anti-cancer; antidiabetic; cisplatin; vanadium; DNA-BINDING PROPERTIES; INSULIN-MIMETIC AGENT; CELL-CYCLE ARREST; VANADIUM COMPOUNDS; PLATINUM COMPLEX; OXOVANADIUM(IV) COMPLEXES; SKELETAL-MUSCLE; GENE-EXPRESSION; DIABETIC-RATS; CANCER-CELLS;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
From this century, great progresses have been made in the field of metal-based medicine and relevant fundamental researches. However, there are also major problems left to be solved. This review summarized the recent progresses and the bottlenecks of two important metal drugs, anti-cancer platinum/non-platinum drugs and anti-diabetic vanadium compounds. The following aspects are proposed for attentions in the future research: (1) Discover new molecular mechanism of metal drugs for rational design of metal drugs; (2) Control of metal toxicity based on molecular mechanism; (3) Rational metal drug design and metal drug delivery system based on nano materials, molecular complexes and drug transporters; (4) Synthetic biology of metal complexes.
引用
收藏
页码：650 / 660
页数：11
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