Identification of a Novel Genomic Island Associated with vanD-Type Vancomycin Resistance in Six Dutch Vancomycin-Resistant Enterococcus faecium Isolates

被引：1

作者：

Top, Janetta ^{[1
]}

Sinnige, Jan C. ^{[1
,9
]}

Brouwer, Ellen C. ^{[1
]}

Werner, Guido ^{[2
]}

Corander, Jukka ^{[3
,4
,5
]}

Severin, Juliette A. ^{[6
]}

Jansen, Rogier ^{[7
]}

Bathoorn, E. ^{[8
]}

Bonten, Marc J. M. ^{[1
]}

Rossen, John W. A. ^{[8
]}

Willems, Rob J. L. ^{[1
]}

机构：

[1] Univ Med Ctr Utrecht, Dept Med Microbiol, Utrecht, Netherlands

[2] Robert Koch Inst, Wernigerode Branch, Dept Infect Dis, Div Nosocomial Pathogens & Antibiot Resistance, Wernigerode, Germany

[3] Univ Oslo, Dept Biostat, Fac Med, Oslo, Norway

[4] Univ Helsinki, Dept Math & Stat, Helsinki, Finland

[5] Wellcome Trust Sanger Inst, Infect Genom, Hinxton, Cambs, England

[6] Erasmus Univ, Med Ctr, Dept Med Microbiol & Infect Dis, Rotterdam, Netherlands

[7] OLVG, Dept Med Microbiol, Amsterdam, Netherlands

[8] Univ Med Ctr Groningen, Dept Med Microbiol, Groningen, Netherlands

[9] Reg Lab Publ Hlth Haarlem, Haarlem, Netherlands

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2018年 / 62卷 / 03期

基金：

欧洲研究理事会;

关键词：

Enterococcus faecium; genomic island; vanD type; vancomycin resistance; MOLECULAR CHARACTERIZATION; CONJUGATIVE ELEMENTS; GENE-CLUSTER; FAECALIS; CANADA; FLORA;

D O I：

10.1128/AAC.01793-17

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Genomic comparison of the first six Dutch vanD-type vancomycin-resistant Enterococcus faecium (VRE) isolates with four vanD gene clusters from other enterococcal species and anaerobic gut commensals revealed that the vanD gene cluster was located on a genomic island of variable size. Phylogenetic inferences revealed that the Dutch VRE isolates were genetically not closely related and that genetic variation of the vanD-containing genomic island was not species specific, suggesting that this island is transferred horizontally between enterococci and anaerobic gut commensals.

引用

页数：7

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