Targeting Hedgehog (Hh) Pathway for the Acute Myeloid Leukemia Treatment

被引：46

作者：

Terao, Toshiki ^{[1
,2
]}

Minami, Yosuke ^{[1
]}

机构：

[1] Natl Canc Ctr Hosp East, Dept Hematol, Kashiwa, Chiba 2778577, Japan

[2] Kameda Med Ctr, Dept Internal Med, Div Hematol Oncol, Kamogawa 2968602, Japan

来源：

CELLS | 2019年 / 8卷 / 04期

关键词：

Hedgehog pathway; acute myeloid leukemia; AML; leukemic stem cell; glioma; Smoothened; glasdegib; sonidegib; STEM-CELLS; MYELODYSPLASTIC SYNDROME; GLASDEGIB PF-04449913; CLINICAL-IMPLICATIONS; PHASE IB; GLI; INHIBITOR; MUTATIONS; ACTIVATION; THERAPY;

D O I：

10.3390/cells8040312

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The Hedgehog (Hh) pathway, containing the Patched (PTCH) and Smoothened (SMO) multitransmembrane proteins, is the main regulator of vertebrate embryonic development. A non-canonical Hh pathway was recently observed in numerous types of solid cancers and hematological malignancies. Although acute myeloid leukemia (AML) is a common and lethal myeloid malignancy, the chemotherapy for AML has not changed in the last three decades. The Hh pathway and other intracellular signaling pathways are important for the tumor cells' cycle or therapeutic resistance of AML cells. In this article, we will review the current trends in Hh pathway inhibitors for treating AML.

引用

页数：11

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