SPERM QUALITY IN ADULT MALE RATS EXPOSED TO CADMIUM IN UTERO AND LACTATION

被引：13
|
作者：
Banzato, Thais Petrochelli [2 ]
Godinho, Antonio Francisco [3 ]
Mathias da Silva Zacarin, Elaine Cristina [4 ]
Perobelli, Juliana Elaine [5 ]
Fernandez, Carla Dal Bianco [5 ]
Alves Favareto, Ana Paula [5 ]
Kempinas, Wilma De Grava [1 ]
机构：
[1] UNESP Univ Estadual Paulista, Dept Morphol, Inst Biosci, BR-18618970 Botucatu, SP, Brazil
[2] UNESP Univ Estadual Paulista, Grad Program Gen & Appl Biol, Inst Biosci, BR-18618970 Botucatu, SP, Brazil
[3] UNESP Univ Estadual Paulista, Ctr Toxicol Assistance CEATOX, Inst Biosci, BR-18618970 Botucatu, SP, Brazil
[4] Fed Univ Sao Carlos UFSCAR, Lab Struct & Funct Biol, Campus Sorocaba, SP, Brazil
[5] State Univ Campinas UNICAMP, Inst Biol, Grad Program Cellular & Struct Biol, Campinas, SP, Brazil
来源：
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES | 2012年 / 75卷 / 16-17期
基金：
巴西圣保罗研究基金会;
关键词：
SEMEN QUALITY; REPRODUCTIVE-PERFORMANCE; LEAD; ZINC; TOXICITY; TESTIS; LEVEL; LIVER; GENOTOXICITY; PLACENTAS;
D O I：
10.1080/15287394.2012.697831
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
Recent studies indicate that several anomalies of the male reproductive system may be produced by acute or chronic exposure to chemical substances released into the environment, attributed to increased industrial development. Among these substances are trace metals such as cadmium (Cd). The aim of this study was to assess reproductive parameters in adult male rats whose mothers were exposed to Cd during pregnancy and lactation. For this, pregnant rats were divided into two experimental groups: treated rats, which received ad libitum cadmium acetate (CdAc) solution in distilled water (10 mg Cd/L), and control rats, which received sodium acetate (NaAc) solution in distilled water (equimolar to the CdAc). The results showed that the exposure to Cd in utero and through lactation adversely affected sperm quality of adult rats, as evidenced by compromised sperm morphology and motility and increased rate of cell death in testis.
引用
收藏
页码：1047 / 1058
页数：12
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