Broad-Spectrum Antimicrobial and Biofilm-Disrupting Hydrogels: Stereocomplex-Driven Supramolecular Assemblies

被引：127
|
作者：
Li, Yan [1 ,2 ]
Fukushima, Kazuki [5 ]
Coady, Daniel J. [6 ]
Engler, Amanda C. [6 ]
Liu, Shaoqiong [1 ]
Huang, Yuan [3 ]
Cho, John S. [4 ]
Guo, Yi [4 ]
Miller, Lloyd S. [4 ]
Tan, Jeremy P. K. [1 ]
Ee, Pui Lai Rachel [2 ]
Fan, Weimin [3 ]
Yang, Yi Yan [1 ]
Hedrick, James L. [6 ]
机构：
[1] Inst Bioengn & Nanotechnol, Singapore 138669, Singapore
[2] Natl Univ Singapore, Dept Pharm, Singapore 117543, Singapore
[3] Zhejiang Univ, Coll Med, Affiliated Hosp 1, Program Innovat Therapeut, Hangzhou 310003, Zhejiang, Peoples R China
[4] Univ Calif Los Angeles, Div Dermatol, Ctr Hlth Sci 52 121, Los Angeles, CA 90095 USA
[5] Yamagata Univ, Dept Polymer Sci & Engn, Yonezawa, Yamagata 9928510, Japan
[6] IBM Almaden Res Ctr, San Jose, CA 95120 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 02期
关键词：
biofilms; gels; electron microscopy; noncovalent interactions; supramolecular chemistry; SELF-ORGANIZATION; PLLA-PEG; COPOLYMERS; DIBLOCK;
D O I：
10.1002/anie.201206053
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Fighting the resistance: Biodegradable and injectable/moldable hydrogels with hierarchical nanostructures (see picture) were made with broad-spectrum antimicrobial activities and biofilm-disruption capability. They demonstrate no cytotoxicity in vitro, and show excellent skin biocompatibility in animals. These hydrogels have great potential for clinical use in prevention and treatment of various multidrug-resistant infections. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：674 / 678
页数：5
相关论文
共 17 条
  • [1] Functional Silver Nanocomposites as Broad-Spectrum Antimicrobial and Biofilm-Disrupting Agents
    Guo, Qanqian
    Zhao, Yu
    Dai, Xiaomei
    Zhang, Tianqi
    Yu, Yunjian
    Zhang, Xinge
    Li, Chaoxing
    ACS APPLIED MATERIALS & INTERFACES, 2017, 9 (20) : 16835 - 16848
  • [2] Broad-Spectrum Antimicrobial Supramolecular Assemblies with Distinctive Size and Shape
    Fukushima, Kazuki
    Tan, Jeremy P. K.
    Korevaar, Peter A.
    Yang, Yi Yan
    Pitera, Jed
    Nelson, Alshakim
    Maune, Hareem
    Coady, Daniel J.
    Frommer, Jane E.
    Engler, Amanda C.
    Huang, Yuan
    Xu, Kaijin
    Ji, Zhongkang
    Qiao, Yuan
    Fan, Weimin
    Li, Lanjuan
    Wiradharma, Nikken
    Meijer, E. W.
    Hedrick, James L.
    ACS NANO, 2012, 6 (10) : 9191 - 9199
  • [3] Supramolecular antimicrobial hydrogels with broad spectrum activity
    Li, Yan
    Fukushima, Kazuki
    Liu, Shaoqiong
    Yang, Yi-Yan
    Yang, Yi-Yan
    Coady, Daniel
    Engler, Amanda
    Hedrick, James L.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2012, 243
  • [4] Broad-Spectrum Antimicrobial Polycarbonate Hydrogels with Fast Degradability
    Pascual, Ana
    Tan, Jeremy P. K.
    Yuen, Alex
    Chan, Julian M. W.
    Coady, Daniel J.
    Mecerreyes, David
    Hedrick, James L.
    Yang, Yi Yan
    Sardon, Haritz
    BIOMACROMOLECULES, 2015, 16 (04) : 1169 - 1178
  • [5] The Effect of a Biofilm-disrupting Wound Gel vs. a Broad-spectrum Antimicrobial Ointment on a Chronic Wound Microbiome: A Secondary Analysis Associating Clinical and Laboratory Findings br
    Myntti, Matthew F.
    Stevenson, Patricia
    Porral, Dianne
    Hayes, Valerie Y.
    WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE, 2022, 34 (12): : E141 - E146
  • [6] Immunization with a Biofilm-Disrupting Nontypeable Haemophilus influenzae Vaccine Antigen Did Not Alter the Gut Microbiome in Chinchillas, Unlike Oral Delivery of a Broad-Spectrum Antibiotic Commonly Used for Otitis Media
    Bailey, Michael T.
    Lauber, Christian L.
    Novotny, Laura A.
    Goodman, Steven D.
    Bakaletz, Lauren O.
    MSPHERE, 2020, 5 (02)
  • [7] Evaluation of the Antimicrobial Peptide, RP557, for the Broad-Spectrum Treatment of Wound Pathogens and Biofilm
    Woodburn, Kathryn Wynne
    Jaynes, Jesse M.
    Clemens, L. Edward
    FRONTIERS IN MICROBIOLOGY, 2019, 10
  • [8] Impact of the broad-spectrum antimicrobial peptide, lacticin 3147, on Streptococcus mutans growing in a biofilm and in human saliva
    Dobson, A.
    O'Connor, P. M.
    Cotter, P. D.
    Ross, R. P.
    Hill, C.
    JOURNAL OF APPLIED MICROBIOLOGY, 2011, 111 (06) : 1515 - 1523
  • [9] Branched High Molecular Weight Glycopolypeptide With Broad-Spectrum Antimicrobial Activity for the Treatment of Biofilm Related Infections
    Mauro, Nicolo
    Schillaci, Domenico
    Varvara, Paola
    Cusimano, Maria Grazia
    Geraci, Daniela Maria
    Giuffre, Mario
    Cavallaro, Gennara
    Maida, Carmelo Massimo
    Giammona, Gaetano
    ACS APPLIED MATERIALS & INTERFACES, 2018, 10 (01) : 318 - 331
  • [10] Community-level assessment of the effects of the broad-spectrum antimicrobial chlorhexidine on the outcome of river microbial biofilm development
    Lawrence, J. R.
    Zhu, B.
    Swerhone, G. D. W.
    Topp, E.
    Roy, J.
    Wassenaar, L. I.
    Rema, T.
    Korber, D. R.
    APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2008, 74 (11) : 3541 - 3550
12