Dipiperamides A, B, and C:: bisalkaloids from the white pepper Piper nigrum inhibiting CYP3A4 activity

被引：43
|
作者：
Tsukamoto, S [1 ]
Cha, BC [1 ]
Ohta, T [1 ]
机构：
[1] Kanazawa Univ, Fac Pharmaceut Sci, Kanazawa, Ishikawa 9200934, Japan
来源：
TETRAHEDRON | 2002年 / 58卷 / 09期
关键词：
bisalkaloids; pepper; cytochrome P450 3A4 inhibitor;
D O I：
10.1016/S0040-4020(02)00048-0
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Three new bisalkaloids, dipiperamides A, B, and C, were isolated from the white pepper (Piper nigrum L.), along with the known piperine and piperylin. Dipiperamides A-C inhibited cytochrome P450 (CYP) 3A4 activity. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：1667 / 1671
页数：5
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