Synthesis of α,β-Unsaturated Ketones by Rhodium-Catalyzed Carbonylative Arylation of Internal Alkynes with Arylboronic Acids

被引：11

作者：

Kus, Melih ^{[1
]}

Artok, Oezge Aksin ^{[1
]}

Ziyanak, Firat ^{[1
]}

Artok, Levent ^{[1
]}

机构：

[1] Izmir Inst Technol, Fac Sci, Dept Chem, TR-35430 Izmir, Turkey

来源：

SYNLETT | 2008年 / 17期

关键词：

carbonylation; boron; rhodium; enones; alkynes;

D O I：

10.1055/s-2008-1078047

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Rh-catalyzed reaction of arylboronic acids with internal alkynes under a CO atmosphere in the presence of an acid additive afforded alpha,beta-unsaturated ketones as the major products. Hydroacylation of internal alkynes, except in the case of diaryl acetylenes, proceeded in syn fashion, yielding the E-configured isomer. A mixture of E- and Z-isomers was obtained with diphenyl acetylene. Reactions were also highly regioselective for various nonsymmetric alkynes.

引用

页码：2587 / 2592

页数：6

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