Hybrid Model of Erythropoiesis

被引：10
|
作者：
Kurbatova, P. [1 ]
Eymard, N. [2 ]
Volpert, V. [2 ]
机构：
[1] Fac Med Laennec, UMR 5558, Lyon, France
[2] Univ Lyon 1, CNRS, UMR 5208, Inst Camille Jordan, F-69622 Villeurbanne, France
来源：
ACTA BIOTHEORETICA | 2013年 / 61卷 / 03期
关键词：
Hybrid model; Erythropoiesis; Erythroblastic island; macrophage; Regulatory mechanisms; CELL-BASED MODEL; ERYTHROBLASTIC ISLANDS; VASCULAR NETWORKS; PROGENITOR CELLS; TUMOR-GROWTH; INVASION; CANCER; DIFFERENTIATION; PROLIFERATION; STRATEGIES;
D O I：
10.1007/s10441-013-9188-2
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
A hybrid model of cell dynamics is presented. It is illustrated by model examples and applied to study erythropoiesis (red blood cell production). In this approach, cells are considered as discrete objects while intra-cellular proteins and extra-cellular biochemical substances are described with continuous models. Spatial organization of erythropoiesis occurring in specific structures of the bone marrow, called erythroblastic island, is investigated.
引用
收藏
页码：305 / 315
页数：11
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