A ratiometric fluorescent probe for detection of exogenous mitochondrial SO2 based on a FRET mechanism

被引：24
|
作者：
Xu, Zhiyang [1 ]
Chen, Zhen [1 ]
Liu, Aikun [1 ]
Ji, Ruixue [1 ]
Cao, Xiaoqun [1 ]
Ge, Yanqing [1 ]
机构：
[1] Taishan Med Univ, Sch Chem & Pharmaceut Engn, Tai An 271000, Shandong, Peoples R China
来源：
RSC ADVANCES | 2019年 / 9卷 / 16期
关键词：
SULFUR-DIOXIDE DERIVATIVES; ENDOGENOUSLY GENERATED SO2; SELECTIVE DETECTION; OPTICAL-PROPERTIES; RAPID DETECTION; BISULFITE; SULFITE; HG2+; FLUOROPHORE; INDOLIZINE;
D O I：
10.1039/c8ra10328c
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel imidazo[1,5-a]pyridine-hemicyanine based ratiometric fluorescent probe for detection of mitochondrial SO2 was designed and synthesized. The probe is based on a fluorescence resonance energy transfer (FRET) mechanism. It exhibits high selectivity and sensitivity towards SO32- with a fast response time (3 min) and detection limit of 0.13 M. Further, it showed low cytotoxicity and was successfully applied to image exogenous mitochondrial SO2 in cells.
引用
收藏
页码：8943 / 8948
页数：6
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