Pestalachlorides A-C, antifungal metabolites from the plant endophytic fungus Pestalotiopsis adusta

被引：166
|
作者：
Li, Erwei [1 ]
Jiang, Lihua [1 ]
Guo, Liangdong [1 ]
Zhang, Hua [2 ]
Che, Yongsheng [1 ]
机构：
[1] Chinese Acad Sci, Inst Microbiol, Key Lab Systemat Mycol & Lichenol, Beijing 100080, Peoples R China
[2] N China Pharmaceut Grp Corp, New Drug Res & Dev Ctr, Shijiazhuang 050015, Peoples R China
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2008年 / 16卷 / 17期
基金：
中国国家自然科学基金;
关键词：
Pestalotiopsis adusta; pestalachlorides; antifungal; atropisomer; racemate;
D O I：
10.1016/j.bmc.2008.07.075
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Pestalachlorides A-C (1-3), three new chlorinated benzophenone derivatives, have been isolated from cultures of an isolate of the plant endophytic fungus Pestalotiopsis adusta. The structures of these compounds were determined mainly by NMR spectroscopy, and the structures of 1 and 3 were further confirmed by X-ray crystallography. Pestalachloride A (1) was obtained as a mixture of two inseparable atropisomers (1a and 1b), whereas pestalachloride C (3) was found to be a racemic mixture. Compounds 1 and 2 displayed significant antifungal activities against three plant pathogens. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：7894 / 7899
页数：6
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