Sonic hedgehog elevates N-myc gene expression in neural stem cells

被引：3

作者：

Liu, Dongsheng ^{[1
]}

Wang, Shouyu ^{[1
]}

Cui, Yan ^{[1
]}

Shen, Lun ^{[1
]}

Du, Yanping ^{[1
]}

Li, Guilin ^{[2
]}

Zhang, Bo ^{[1
]}

Wang, Renzhi ^{[2
]}

机构：

[1] Dalian Med Univ, Dept Neurosurg, Affiliated Hosp 1, Dalian 116011, Liaoning Provin, Peoples R China

[2] Chinese Acad Med Sci, Dept Neurosurg, Peking Union Med Coll Hosp, Beijing 100730, Peoples R China

来源：

NEURAL REGENERATION RESEARCH | 2012年 / 7卷 / 22期

基金：

中国国家自然科学基金;

关键词：

stem cells; neural stem cells; sonic hedgehog signal pathway; N-myc gene; proliferation; target gene; neural regeneration; PRECURSOR PROLIFERATION; NEURONAL PRECURSORS; NERVOUS-SYSTEM; BRAIN; PROGENITORS; PROGRESSION; INDUCTION; BEHAVIOR; PATHWAY;

D O I：

10.3969/j.issn.1673-5374.2012.22.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Proliferation of neural stem cells is regulated by the secreted signaling molecule sonic hedgehog. In this study, neural stem cells were infected with recombinant adeno-associated virus expressing sonic hedgehog-N-enhanced green fluorescent protein. The results showed that overexpression of sonic hedgehog in neural stem cells induced the increased expression of Gli1 and N-myc, a target gene of sonic hedgehog. These findings suggest that N-myc is a direct downstream target of the sonic hedgehog signal pathway in neural stem cells. Sonic hedgehog and N-myc are important mediators of sonic hedgehog-induced proliferation of neural stem cells.

引用

页码：1703 / 1708

页数：6

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