Testicular adrenal rest tumors (TART) in adult men with classic congenital adrenal hyperplasia (CAH)

被引：0
|
作者：
Knape, P. [1 ]
Reisch, N. [2 ]
Doerr, H. -G. [3 ]
Reincke, M. [2 ]
Lenk, S. [4 ]
Quinkler, M. [1 ]
机构：
[1] Charite, Klin Endokrinol, D-10117 Berlin, Germany
[2] Klinikum LMU, Med Klin Innenstadt, Munich, Germany
[3] Univ Kinderklin, Abt Padiatr Endokrinol, Erlangen, Germany
[4] Charite, Klin & Poliklin Urol, D-10117 Berlin, Germany
来源：
UROLOGE | 2008年 / 47卷 / 12期
关键词：
Testicular adrenal rest tumors; Congenital adrenal hyperplasia; Fertility; Adrenal crisis; Virilization;
D O I：
10.1007/s00120-008-1857-4
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Background. Information about treatment of adult male patients with congenital adrenal hyperplasia (CAH) and testicular adrenal rest tumors (TART) is scarce. Diagnostic and therapeutic guidelines do not exist. The aim of this review is to evaluate the current state of therapeutic options in adult male patients with CAH. Methods. We performed an extensive search of the literature of the last 10 years by using PubMed/MEDLINE. Results. The aims of treatment in adult male patients with CAH are prevention of adrenal crisis and TART, improvement of general wellbeing, good quality of life and sexual well-being, fertility, and prevention of side effects of gluco-and mineralocorticoid therapy. However, fertility is impaired in these patients and correlates with TART. The current therapeutic concepts are discussed. Conclusions. A future system of regular follow-up visits and standards in therapeutic concepts is needed to guarantee an improved fertility and lifelong good quality of life in adult male patients with CAH.
引用
收藏
页码：1596 / 1602
页数：7
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