Quantitative trait loci for resistance to Heligmosomoides bakeri and associated immunological and pathological traits in mice: comparison of loci on chromosomes 5, 8 and 11 in F2 and F6/7 inter-cross lines of mice

被引：5
|
作者：
Behnke, J. M. [1 ]
Menge, D. M. [2 ]
Nagda, S. [2 ]
Noyes, H. [3 ]
Iraqi, F. A. [2 ]
Kemp, S. J. [3 ]
Mugambi, R. J. M. [2 ]
Baker, R. L. [2 ]
Wakelin, D. [1 ]
Gibson, J. P. [2 ]
机构：
[1] Univ Nottingham, Sch Biol, Nottingham NG7 2RD, England
[2] ILRI, Nairobi, Kenya
[3] Univ Liverpool, Sch Biol Sci, Liverpool L69 7ZB, Merseyside, England
来源：
PARASITOLOGY | 2010年 / 137卷 / 02期
基金：
英国惠康基金;
关键词：
Heligmosomoides bakeri; Heligmosomoides polygyrus; QTL; resistance; nematodes; antibody; IgG1; Mcpt1; MCPT1; granulomatous response; GASTROINTESTINAL NEMATODE INFECTIONS; REGIONS CONTROLLING RESISTANCE; NEMATOSPIROIDES-DUBIUS; POLYGYRUS NEMATOSPIROIDES; RESPONSES; GENES; MOUSE; SHEEP; GENETICS; IMMUNITY;
D O I：
10.1017/S0031182009991028
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
A comparison of F2 and F6/7 inter-cross lines of mice, derived from CBA kind SWR parental strains, has provided strong evidence for several previously undetected quantitative trait loci (QTL) for resistance to Heligmosomoides bakeri. Five QTL affecting average faecal egg Counts and/or worm burdens in week 6 were detected on mouse chromosomes 5 (Hbnr9 and Hbnr10), 8 (Hbnr11) and 11 (Hbnr13 and Hbnr14). Three QTL for faecal egg counts in weeks 4 and 6 were found oil both chromosomes 5 (Hbnr9) and 11 (Hbnr13 and Hbnr14). Two QTL for the mucosal mast cell protease I (MCPT1) response were located on chromosomes 8 (Hbnr11) and 11 (Hbnr13), two for the IgG1 antibody response to adult worms on chromosomes 5 (Hbnr10) and 8 (Hbnr11), two for PCV in week 6 on chromosomes 5 (Hbnr9) and I I (Hbnr13), and two for the granulomatous response on chromosome 8 (Hbnr12) and I I (Hbnr15). Our data emphasize that the control of resistance to H. bakeri is multigenic, and regulated by genes within QTL regions that have a complex range of hierarchical relationships.
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收藏
页码：311 / 320
页数：10
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