Ventral striatal hyporesponsiveness during reward anticipation in attention-deficit/hyperactivity disorder

被引:360
|
作者
Scheres, Anouk
Milham, Michael P.
Knutson, Brian
Castellanos, Francisco Xavier
机构
[1] Univ Arizona, Dept Psychol, Tucson, AZ 85721 USA
[2] NYU, Ctr Child Study, Inst Pediat Neurosci, New York, NY USA
[3] Stanford Univ, Stanford, CA 94305 USA
关键词
ADHD; attention-deficit/hyperactivity disorder; fMRI; impulsivity; reward; striatum;
D O I
10.1016/j.biopsych.2006.04.042
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background: Although abnormalities in reward processing have been proposed to underlie attention-deficit/hyperactivity disorder (ADHD), this link has not been tested explicitly with neural probes. Methods: This hypothesis was tested by using fMRI to compare neural activity within the striatum in individuals with ADHD and healthy controls during a reward-anticipation task that has been shown previously to produce reliable increases in ventral striatum activity in healthy adults and healthy adolescents. Eleven adolescents with ADHD (5 off medication and 6 medication-naive) and 11 healthy controls (ages 12-17 y) were included. Groups were matched for age, gender, and intelligence quotient. Results: We found reduced ventral striatal activation in adolescents with ADHD during reward anticipation, relative to healthy controls. Moreover, ventral striatal activation was negatively correlated with parent-rated hyperactive/impulsive symptoms across the entire sample. Conclusions: These findings provide neural evidence that symptoms of ADHD, and impulsivity or hyperactivity in particular, may involve diminished reward anticipation, in addition to commonly observed executive dysfunction.
引用
收藏
页码:720 / 724
页数:5
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