The genetics of gene expression in complex mouse crosses as a tool to study the molecular underpinnings of behavior traits

被引：8

作者：

Hitzemann, Robert ^{[1
,2
]}

Bottomly, Daniel ^{[3
]}

Iancu, Ovidiu ^{[2
]}

Buck, Kari ^{[1
,2
]}

Wilmot, Beth ^{[3
,4
]}

Mooney, Michael ^{[4
]}

Searles, Robert ^{[5
]}

Zheng, Christina ^{[4
]}

Belknap, John ^{[1
,2
]}

Crabbe, John ^{[1
,2
]}

McWeeney, Shannon ^{[1
,3
,4
,6
]}

机构：

[1] Vet Affairs Med Ctr, Portland Alcohol Res Ctr, Portland, OR 97239 USA

[2] Oregon Hlth & Sci Univ, Dept Behav Neurosci, Portland, OR 97239 USA

[3] Oregon Hlth & Sci Univ, Oregon Clin & Translat Res Inst, Portland, OR 97239 USA

[4] Oregon Hlth & Sci Univ, Dvis Bioinformat & Computat Biol, Portland, OR 97239 USA

[5] Oregon Hlth & Sci Univ, Integrated Genom Lab, Portland, OR 97239 USA

[6] Oregon Hlth & Sci Univ, Div Biostat Publ Hlth & Preventat Med, Portland, OR 97239 USA

来源：

MAMMALIAN GENOME | 2014年 / 25卷 / 1-2期

关键词：

RECOMBINANT INBRED STRAINS; COEXPRESSION NETWORK ANALYSIS; SINGULAR-VALUE DECOMPOSITION; HETEROGENEOUS STOCK MICE; GENOME-WIDE ASSOCIATION; COLLABORATIVE CROSS; DIFFERENTIAL EXPRESSION; STRUCTURED POPULATIONS; REGULATORY VARIATION; QUANTITATIVE TRAITS;

D O I：

10.1007/s00335-013-9495-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Complex Mus musculus crosses provide increased resolution to examine the relationships between gene expression and behavior. While the advantages are clear, there are numerous analytical and technological concerns that arise from the increased genetic complexity that must be considered. Each of these issues is discussed, providing an initial framework for complex cross study design and planning.

引用

页码：12 / 22

页数：11

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