Comparative genomic hybridization study of primary neuroblastoma tumors

被引：0
|
作者：
Lastowska, M
Nacheva, E
McGuckin, A
Curtis, A
Grace, C
Pearson, A
Bown, N
机构：
[1] UNIV NEWCASTLE, DEPT CHILD HLTH, NEWCASTLE UPON TYNE NE2 4AA, TYNE & WEAR, ENGLAND
[2] UNIV NEWCASTLE, CANC RES UNIT, NEWCASTLE UPON TYNE NE2 4AA, TYNE & WEAR, ENGLAND
[3] UNIV CAMBRIDGE, ADDENBROOKES HOSP, DEPT HAEMATOL, CAMBRIDGE CB2 1TN, ENGLAND
[4] ROYAL VICTORIA INFIRM, DEPT PATHOL, NEWCASTLE UPON TYNE NE1 4LP, TYNE & WEAR, ENGLAND
[5] DIGITAL SCI LTD, CAMBRIDGE, ENGLAND
[6] INST PAEDIAT, CLIN PAEDIAT HAEMATOL & ONCOL, POZNAN, POLAND
来源：
GENES CHROMOSOMES & CANCER | 1997年 / 18卷 / 03期
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Neuroblastoma tumors show a complex interaction of genetic abnormalities, among which some are of significant prognostic importance; however, analysis of chromosome changes in this tumor is often unsuccessful. Twenty primary tumors were studied by comparative genomic hybridization (CGH), and abnormalities were found in 19. While these changes included deletions of chromosome arm 1p (45%) and MYCN oncogene amplification (30%), gains of chromosome 17 material were much more frequent (75%). We also found evidence in two cases of a new amplification site at band 2p23. (C) 1997 Wiley-Liss, Inc.
引用
收藏
页码：162 / 169
页数：8
相关论文
共 50 条
  • [1] Olfactory neuroblastoma: Detection of genomic imbalances by comparative genomic hybridization
    Szymas, J
    Wolf, G
    Kowalczyk, D
    Nowak, S
    Petersen, I
    ACTA NEUROCHIRURGICA, 1997, 139 (09) : 839 - 844
  • [2] Olfactory neuroblastoma: Detection of genomic imbalances by comparative genomic hybridization
    J. Szymas
    G. Wolf
    D. Kowalczyk
    S. Nowak
    I. Petersen
    Acta Neurochirurgica, 1997, 139 : 839 - 844
  • [3] Comparative genomic hybridization in cartilaginous tumors
    Ozaki, T
    Wai, D
    Schäfer, KL
    Lindner, N
    Böcker, W
    Winkelmann, W
    Dockhorn-Dworniczak, B
    Poremba, C
    ANTICANCER RESEARCH, 2004, 24 (3A) : 1721 - 1725
  • [4] Chromosomal localization of DNA amplifications in neuroblastoma tumors using cDNA microarray comparative genomic hybridization
    Beheshti, B
    Braude, I
    Marrano, P
    Thorner, P
    Zielenska, M
    Squire, JA
    NEOPLASIA, 2003, 5 (01): : 53 - 62
  • [5] Array comparative genomic hybridization analysis of olfactory neuroblastoma
    Guled, Mohamed
    Myllykangas, Samuel
    Frierson, Henry F., Jr.
    Mills, Stacey E.
    Knuutila, Sakari
    Stelow, Edward B.
    MODERN PATHOLOGY, 2008, 21 (06) : 770 - 778
  • [6] Genetic heterogeneity of neuroblastoma studied by comparative genomic hybridization
    Vandesompele, J
    Van Roy, N
    Van Gele, M
    Laureys, G
    Ambros, P
    Heimann, P
    Devalck, C
    Schuuring, E
    Brock, P
    Otten, J
    Gyselinck, J
    De Paepe, A
    Speleman, F
    GENES CHROMOSOMES & CANCER, 1998, 23 (02): : 141 - 152
  • [7] Olfactory neuroblastoma: Detection of genomic imbalances by comparative genomic hybridization - Comment
    Kleihues, P
    ACTA NEUROCHIRURGICA, 1997, 139 (09) : 844 - 844
  • [8] Comparative genomic hybridization in pineal parenchymal tumors
    Rickert, CH
    Simon, R
    Bergmann, M
    Dockhorn-Dworniczak, B
    Paulus, W
    GENES CHROMOSOMES & CANCER, 2001, 30 (01): : 99 - 104
  • [9] Comparative genomic hybridization analysis of Wilms tumors
    Steenman, M
    Redeker, B
    deMeulemeester, M
    Wiesmeijer, K
    Voute, PA
    Westerveld, A
    Slater, R
    Mannens, M
    CYTOGENETICS AND CELL GENETICS, 1997, 77 (3-4): : 296 - 303
  • [10] Chromosomal imbalances detected in primary bone tumors by comparative genomic hybridization and interphase fluorescence in situ hybridization
    Baruffi, MR
    Engel, EE
    Squire, JA
    Tone, LG
    Rogatto, SR
    GENETICS AND MOLECULAR BIOLOGY, 2003, 26 (02) : 107 - 113
12345