A new prognostic index model using meta-analysis in early-stage epithelial ovarian cancer

被引:7
|
作者
Park, Hyun Jong [1 ]
Nam, Eun Ji [1 ]
Rha, Sun Young [2 ]
Kim, Sunghoon [1 ]
Kim, Sang Wun [1 ]
Kim, Jae Wool [3 ]
Kim, Young Tae [1 ]
机构
[1] Yonsei Univ, Div Gynecol Oncol, Inst Womens Life Sci, Dept Obstet & Gynecol,Coll Med, Seoul 120752, South Korea
[2] Yonsei Univ, Dept Internal Med, Div Med Oncol, Coll Med, Seoul 120752, South Korea
[3] Kwandong Univ, Coll Med, Dept Obstet & Gynecol, Seoul, South Korea
关键词
Meta-analysis; Early-stage ovarian cancer; Recurrence; Prognostic index; Prognosis factor; Prediction; CLEAR-CELL CARCINOMA; RANDOMIZED CONTROLLED-TRIALS; ADJUVANT CHEMOTHERAPY; SYSTEMATIC REVIEWS; CLINICAL-TRIALS; NEOPLASM TRIAL; SURVIVAL; RISK; IMPACT;
D O I
10.1016/j.ygyno.2012.06.006
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Objectives. To construct a novel prognostic index (PI) model of early-stage epithelial ovarian cancer (EOC). Methods. The PI model was constructed through meta-analyses. The methodological quality of the studies was assessed using the modified Jadad scale for randomized controlled trials (RCTs) and the Newcastle-Ottawa scale for non-RCTs. The prognosis factors of the PI model that had a significant impact on the recurrence-free survival (RFS) of patients with early-stage ovarian cancer were chosen. A total of 177 patients with early-stage ovarian cancer who were treated at Severance Hospital were analyzed using the new PI model to test its utility. Results. The equation PI = 2 x age + 86 (if grade 2) or 105 (if grade 3) + 53 (if stage Ib or Ic) or 130 (if stage II) + 53 (if no lymphadenectomy) - 43 (for adjuvant chemotherapy of 3 times or more) + 10 (calibrating constant) was derived. Based on PI values, the high-risk group showed a significant 5 year-RFS difference compared to the low-risk group (P-value<0.01 by log-rank test) and a borderline significance in comparison to the intermediate-risk group (P-value = 0.08). When the cutoff level of PI values was set at 211, the low- and high-risk groups of recurrence within 5 years were also identified by Cox regression analysis (HR = 7.25, 95% Cl: 2.98-17.65). Conclusions. Our PI model was predictive in this study and may be effective in clinical practice. Further prospective studies should be conducted to confirm the predictive ability of the new PI model for early-stage EOC recurrence. (C) 2012 Elsevier Inc. All rights reserved.
引用
收藏
页码:357 / 363
页数:7
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