Parental urinary biomarkers of preconception exposure to bisphenol A and phthalates in relation to birth outcomes

被引:71
|
作者
Smarr, Melissa M. [1 ]
Grantz, Katherine L. [1 ]
Sundaram, Rajeshwari [1 ]
Maisog, Jose M. [1 ]
Kannan, Kurunthachalam [2 ,3 ]
Louis, Germaine M. Buck [1 ]
机构
[1] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Div Intramural Populat Hlth Res, NIH, Rockville, MD 20852 USA
[2] New York State Dept Hlth, Div Environm Hlth Sci, Wadsworth Ctr, Albany, NY USA
[3] SUNY Albany, Dept Environm Hlth Sci, Albany, NY 12222 USA
来源
ENVIRONMENTAL HEALTH | 2015年 / 14卷
基金
美国国家卫生研究院;
关键词
Bisphenol A; Phthalates; Preconception exposure; Birth weight; Head circumference; Ponderal index; Endocrine disruptors; DI(2-ETHYLHEXYL)PHTHALATE DEHP; TEMPORAL VARIABILITY; PROSPECTIVE COHORT; CIGARETTE-SMOKING; MATERNAL EXPOSURE; OXIDATIVE STRESS; ENVIRONMENT LIFE; COUPLE FECUNDITY; DETECTION LIMITS; US POPULATION;
D O I
10.1186/s12940-015-0060-5
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Background: Bisphenol A (BPA) and phthalates are ubiquitous non-persistent endocrine disrupting chemicals whose relation with infant birth size is not clearly understood. Methods: We examined associations between maternal and paternal preconception urinary concentrations of total BPA and 14 phthalate metabolites and birth size for 233 infants. Multiple linear regression models were used to estimate parental quartiles of BPA and phthalates in relation to birth weight, length, head circumference, and ponderal index with separate models run for each parent adjusting for age, smoking, body mass index, education, alcohol, parity, and creatinine. Models also included an interaction term for each chemical and infant sex and were further adjusted to include the other partner's chemical concentrations. Results: In maternal models adjusted for partner's exposure and covariates, reductions in birth weight (range: 178-215 g; p < 0.05) were observed for the 2nd quartile of maternal monomethyl phthalate, mono-[(2-carboxymethyl) hexyl] phthalate and mono-n-octyl phthalate when compared with the 1st quartiles. The 3rd quartile of monoethylhexyl phthalate (mEHP) was also associated with a 200.16 g (95 % CI: -386.90, -13.42) reduction. Similar reductions in birth weight were observed for the 2nd quartile of paternal mEHP (beta = -191.93 g; 95 % CI: -381.61, -2.25). Additionally, select maternal urinary metabolites were associated with decreased head circumference, birth length and gestational age. However, paternal concentrations were generally associated with increased birth length and gestational age. Conclusions: We observed some suggestion that preconception maternal and paternal urinary concentration of BPA and specific phthalate metabolites may be associated with smaller birth size and increased gestational age, though the findings appeared to be parent and chemical specific.
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页数:11
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