Natural Killer Cell Immunoglobulin-like Receptor (KIR) genotypes in Follicular Lymphoma patients: Results of a pilot study

被引：5
|
作者：
Khalaf, Roy [1 ]
Hoteit, Rouba [2 ]
Yazbek, Soha [3 ,4 ]
El Hajj, Nady [2 ]
Otrock, Zaher [2 ]
Khansa, Sarah [2 ]
Sabbagh, Amira [2 ]
Shammaa, Dina [2 ]
Mahfouz, Rami [2 ]
机构：
[1] Lebanese Amer Univ, Dept Biol, Byblos, Lebanon
[2] AUBMC, Dept Pathol & Lab Med, Beirut, Lebanon
[3] AUBMC, Fac Hlth Sci, Beirut, Lebanon
[4] AUBMC, Dept Biochem, Beirut, Lebanon
来源：
GENE | 2013年 / 525卷 / 01期
关键词：
Follicular; Lymphoma; KIR; Genotype; Lebanon; INHIBITORY RECEPTORS; NK CELLS; EXPRESSION; MECHANISMS; SUBSET; LIGAND;
D O I：
10.1016/j.gene.2013.03.144
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Aims: The Natural Killer Cell Immunoglobulin-like Receptor (KIR) genotype profiling in Follicular Lymphoma has not been reported before in the literature. Materials and methods: DNA extracted from 20 Follicular Lymphoma patients and 62 healthy controls was analyzed for KIR genotyping using a polymerase chain reaction/sequence specific primers technique (PCR/SSP) for the presence of 16 KIR gene and pseudogene loci. Results: The AA, AB, and BB genotype frequencies were, respectively, 20%, 60% and 20% with an A:B ratio of 1:1. KIR 2DL4, KIR 3DL2, KIR 3DL3, and KIR 3DP1*003 were presented in all individuals. No significant difference between patients and controls was detected. Conclusion: KIR genotyping profile does not seem to be associated with Follicular Lymphoma. The results presented in this pilot research represent the first international report about this important clinical entity. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码：136 / 140
页数：5
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