Deprotonation of synthetic polyadenyl-polyuridyl acid in aqueous solution

被引：3
|
作者：
Kudrev, AG [1 ]
机构：
[1] St Petersburg State Univ, St Petersburg, Russia
来源：
RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2001年 / 71卷 / 07期
关键词：
D O I：
10.1023/A:1013174225444
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Ultraviolet and circular dichroism spectroscopies were used to examine the acid-base equilibrium of a double-helix synthetic polyadenyl-polyuridyl Poly(A)-Poly(U) acid in neutral and alkaline aqueous solutions. The deprotonation initially has a positive cooperativity which changes for negative at the deprotonation degree alpha > 1/2. A model is proposed, that explains the titration curves and the complex dependence of pK(a) on pH for Poly(A)-Poly(U) in going from the neutral to alkaline region. The model is based on the allowance for the effect of immediate environment on the internal protonation constant of ideal polymer.
引用
收藏
页码：1109 / 1115
页数：7
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