Adipose tissue dysfunction increases fatty liver association with pre diabetes and newly diagnosed type 2 diabetes mellitus

被引:13
|
作者
Jorge-Galarza, Esteban [1 ]
Medina-Urrutia, Aida [1 ]
Posadas-Sanchez, Rosalinda [1 ]
Posadas-Romero, Carlos [1 ]
Cardoso-Saldana, Guillermo [1 ]
Vargas-Alarcon, Gilberto [2 ]
Caracas-Portilla, Nacu [1 ]
Gonzalez-Salazar, Carmen [1 ]
Torres-Tamayo, Margarita [1 ]
Gabriel Juarez-Rojas, Juan [1 ]
机构
[1] Natl Inst Cardiol Ignacio Chavez, Dept Endocrinol, Juan Badiano 1,Col Secc 16, Mexico City 14080, DF, Mexico
[2] Natl Inst Cardiol Ignacio Chavez, Mol Biol Dept, Mexico City, DF, Mexico
来源
DIABETOLOGY & METABOLIC SYNDROME | 2016年 / 8卷
关键词
Impaired fasting glucose; Type 2 diabetes mellitus; Liver fat; Insulin resistance; Visceral fat; INSULIN-RESISTANCE; ALANINE AMINOTRANSFERASE; METABOLIC SYNDROME; HEPATIC STEATOSIS; VISCERAL FAT; OBESITY; DISEASE; ADIPONECTIN; GLUCOSE; RISK;
D O I
10.1186/s13098-016-0189-6
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: To evaluate the role of adipose tissue function on the association of fatty liver (FL) with impaired fasting glucose (IFG) or newly diagnosed type 2 diabetes mellitus (nT2D). Methods: In 1264 subjects, computed tomography was used to evaluate FL and elevated visceral adipose tissue (VAT). Fasting plasma glucose, <5.6, 5.6-6.9 and >= 7 mmol/l, were used to defined normoglycemic (NG), IFG or nT2D, respectively. Elevated free fatty acids, low serum adiponectin levels and adipose tissue insulin resistance (Adipo-IR), were used as markers of adipose tissue dysfunction. Results: Compared to NG subjects, those with IFG or nT2D had higher prevalence of FL and elevated VAT. FL was found to be independently associated with IFG and nT2D. Adipo-IR increased the association between FL and IFG [OR: 2.46 (95% I.C.: 1.73-3.49) to 5.42 (3.11-9.41)], whereas low adiponectin levels had a higher effect on the FL and nT2D association [OR: 4.26 (2.18-8.34) to 8.53 (2.96-24.55)]. Conclusion: Fatty liver was independently associated with IFG and nT2D. Our results indicate for the first time, that adipose tissue dysfunction increases these associations.
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页码:1 / 8
页数:8
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