Simultaneous determination of salidroside, rosavin, and rosarin in extracts from Rhodiola rosea by high performance liquid chromatography with tandem mass spectrometry detection

被引：13
|
作者：
Rodin, I. A. [1 ]
Stavrianidi, A. N. [1 ]
Braun, A. V. [1 ]
Shpigun, O. A. [1 ]
Popik, M. V. [1 ]
机构：
[1] Moscow MV Lomonosov State Univ, Dept Chem, Moscow 119991, Russia
来源：
JOURNAL OF ANALYTICAL CHEMISTRY | 2012年 / 67卷 / 13期
关键词：
high-performance liquid chromatography/mass spectrometry; electrospray ionization; extraction; plant materials; Rhodiola rosea; salidroside; rosavin; rosarin; RAT PLASMA; IONIZATION; SEPARATION; L;
D O I：
10.1134/S1061934812130096
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
An approach is developed for the simultaneous determination of salidroside, rosarin, and rosavin in extracts from plant based on liquid chromatography/mass spectrometry; the detection limits of the method are 2, 4, and 6 ng/mL for salidroside, rosavin, and rosarin, respectively. The method was validated using real extracts from Rhodiola rosea rhizome. The analysis of extracts was accomplished by reversed-phase chromatography with a SB-C18 stationary phase. The analytes were detected by tandem mass spectrometry with electrospray ionization in the multiple reaction monitoring mode for negative ions.
引用
收藏
页码：1026 / 1030
页数：5
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