Base mediated synthesis of 2-aryl-2,3-dihydroquinazolin-4(1H)-ones from 2-aminobenzonitriles and aromatic aldehydes in water

被引：57
|
作者：
Wu, Xiao-Feng [1 ,2 ]
Oschatz, Stefan [2 ,3 ]
Block, Axel [2 ,3 ]
Spannenberg, Anke [2 ]
Langer, Peter [2 ,3 ]
机构：
[1] Zhejiang Sci Tech Univ, Dept Chem, Hangzhou, Zhejiang, Peoples R China
[2] Univ Rostock, Leibniz Inst Katalyse eV, D-18059 Rostock, Germany
[3] Univ Rostock, Inst Chem, D-18059 Rostock, Germany
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2014年 / 12卷 / 12期
关键词：
ONE-POT SYNTHESIS; BOND FORMATIONS; CHEMISTRY; HETEROCYCLES;
D O I：
10.1039/c3ob42434k
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An environmentally friendly and mild procedure to obtain 2,3-dihydroquinazolin-4(1H)-ones from 2-aminobenzonitriles and aromatic aldehydes has been developed. The reactions took place in water with inorganic base (K3PO4) as the only promoter. Various desired products have been prepared in moderate to good yields under identical conditions. Further transformation of dihydroquinazolinones to quinazolinones was carried out as well with TBHP as the oxidant.
引用
收藏
页码：1865 / 1870
页数：6
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