Synthesis and antifungal properties of arginine-containing hemin derivatives

被引：4

作者：

Zheltukhina, G. A. ^{[1
]}

Okorochenkov, S. A. ^{[1
]}

Groza, N. V. ^{[1
]}

Arzumanyan, V. G. ^{[2
]}

Nebolsin, V. E. ^{[3
]}

机构：

[1] Moscow State Acad Fine Chem Technol MV Lomonosov, Moscow, Russia

[2] Russian Acad Med Sci, Sci Res Inst Vaccines & Sera II Mechnikov, Moscow, Russia

[3] Ltd Liabil Co Pharmenterprises Moscow, Moscow, Russia

来源：

MEDICINAL CHEMISTRY RESEARCH | 2012年 / 21卷 / 11期

关键词：

Hemin; Arginine-containing peptides; Antifungal agents; Candida albicans; Cryptococcus neoformans; 3-HETE; ANTIMICROBIAL ACTIVITY; PEPTIDE; ACIDS;

D O I：

10.1007/s00044-011-9928-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Due to a steadily increasing number of clinical isolates of microscopic fungi that show resistance to conventionally administered antimycotics, the specialists involved have constantly been searching for novel fungicidal agents among various classes of chemical compounds. The present study was aimed at synthesizing and assessing the activity of arginine-containing hemin derivatives against strains of Candida albicans and Cryptococcus neoformans insensitive to commonly used antifungal agents. A hemin conjugate with a branched arginine-containing peptide was shown to exhibit in vitro fungicidal activity at a concentration of 25 mu M and inhibit the growth of the yeast-like fungus Candida albicans at concentrations as low as 12.5 mu M.

引用

页码：3876 / 3884

页数：9

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