IgG4 anti-neurofascin 155 antibodies in chronic inflammatory demyelinating polyradiculoneuropathy: Clinical significance and diagnostic utility of a conventional assay

被引：63

作者：

Kadoya, Masato ^{[1
]}

Kaida, Kenichi ^{[1
]}

Koike, Haruki ^{[2
]}

Takazaki, Hiroshi ^{[1
]}

Ogata, Hidenori ^{[3
]}

Moriguchi, Kota ^{[1
]}

Shimizu, Jun ^{[4
]}

Nagata, Eiichiro ^{[5
]}

Takizawa, Shunya ^{[5
]}

Chiba, Atsuro ^{[6
]}

Yamasaki, Ryo

Kira, Jun-ichi ^{[3
]}

Sobue, Gen ^{[2
]}

Ikewaki, Katsunori ^{[1
]}

机构：

[1] Natl Def Med Coll, Dept Neurol Antiaging & Vasc Med, 3-2 Namiki, Tokorozawa, Saitama 3598513, Japan

[2] Nagoya Univ, Dept Neurol, Grad Sch Med, Nagoya, Aichi 4668550, Japan

[3] Kyushu Univ, Neurol Inst, Grad Sch Med Sci, Dept Neurol,Higashi Ku, Fukuoka 8128582, Japan

[4] Univ Tokyo, Dept Neurol, Bunkyo Ku, Tokyo 1138655, Japan

[5] Tokai Univ, Dept Neurol, Sch Med, Isehara, Kanagawa 2591193, Japan

[6] Kyorin Univ, Dept Neurol, Mitaka, Tokyo 1818611, Japan

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2016年 / 301卷

关键词：

Chronic inflammatory demyelinating; polyradiculoneuropathy; Neurofascin155; IgG4; Antibody; Enzyme-linked immunosorbent assay;

D O I：

10.1016/j.jneuroim.2016.10.013

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We aimed to validate the diagnostic utility of enzyme-linked immunosorbent assay (ELISA) for the detection of anti-neurofascin (NF) 155 antibody in 191 patients with chronic inflammatory demyelinating polyneuropathy (CIDP). Human NF155-based ELISA clearly distinguished between anti-NF155 antibody-positive and -negative sera. Fifteen CIDP patients (8%) were IgG4 anti-human NF155 antibody-positive, which were confirmed by western blot, cell-based assay and immunohistochemical study. None of disease controls or healthy subjects had positive results. Clinical presentation of IgG4 anti-NF155 antibody-positive patients was consistent with those in previous reports. This ELISA combined with determination of the IgG4 subclass is useful in screening for anti-NF155 antibodies. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：16 / 22

页数：7

共 45 条

[1] Diagnostic utility of ELBA for anti-neurofascin 155 antibodies in chronic inflammatory demyelinating polyradiculoneuropathy
Kaida, K.
Kadoya, M.
Koike, H.
Iijima, M.
Takazaki, H.
Ogata, H.
Moriguchi, K.
Shimizu, J.
Nagata, E.
Takizawa, S.
Chiba, A.
Yamasaki, R.
Kira, J.
Sobue, G.
Ikewaki, K.
JOURNAL OF THE NEUROLOGICAL SCIENCES, 2017, 381 : 470 - 471
[2] ANTIBODIES TO NEUROFASCIN155 IN CHRONIC INFLAMMATORY DEMYELINATING POLYRADICULONEUROPATHY: DIAGNOSTIC UTILITY OF A CONVENTIONAL ASSAY
Kaida, K.
Kadoya, M.
Koike, H.
Iijima, M.
Takazaki, H.
Ogata, H.
Moriguchi, K.
Shimizu, J.
Nagata, E.
Takizawa, S.
Chiba, A.
Yamasaki, R.
Kira, J-, I
Sobue, G.
Ikewaki, K.
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM, 2017, 22 (03) : 311 - 311
[3] Nodopathy: chronic inflammatory demyelinating polyneuropathy with anti-neurofascin 155 antibodies
Kuwabara, Satoshi
Misawa, Sonoko
Mori, Masahiro
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2017, 88 (06): : 459 - 459
[4] CLINICAL AND PATHOLOGICAL FEATURES IN FOUR PATIENTS WITH ANTI-NEUROFASCIN 155 IGG4 ANTIBODY-POSITIVE CHRONIC INFLAMMATORY DEMYELINATING POLYNEUROPATHY
Kuwahara, M.
Oka, N.
Ogata, H.
Suzuki, H.
Yanagimoto, S.
Sadakane, S.
Fukumoto, Y.
Yamana, M.
Yuhara, Y.
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Okazaki, M.
Kira, J.
Kusunoki, S.
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM, 2017, 22 (03) : 324 - 324
[5] Neurofascin-155 IgG4 in chronic inflammatory demyelinating polyneuropathy
Devaux, Jerome J.
Miura, Yumako
Fukami, Yuki
Inoue, Takayuki
Manso, Constance
Belghazi, Maya
Sekiguchi, Kenji
Kokubun, Norito
Ichikawa, Hiroo
Wong, Anna Hiu Yi
Yuki, Nobuhiro
NEUROLOGY, 2016, 86 (09) : 800 - 807
[6] Electrophysiological features of chronic inflammatory demyelinating polyradiculoneuropathy associated with IgG4 antibodies targeting neurofascin 155 or contactin 1 glycoproteins
Kouton, Ludivine
Boucraut, Jose
Devaux, Jerome
Rajabally, Yusuf A.
Adams, David
Antoine, Jean Christophe
Bourdain, Frederic
Brodovitch, Alexandre
Camdessanche, Jean-Philippe
Cauquil, Cecile
Ciron, Jonathan
Dubard, Thierry
Echaniz-Laguna, Andoni
Grapperon, Aude-Marie
Juntas-Morales, Raul
Kremer, Laurent
Kuntzer, Thierry
Labeyrie, Celine
Lanfranco, Luca
Leger, Jean-Marc
Maisonobe, Thierry
Mavroudakis, Nicolas
Mecharles-Darrigol, Sylvie
Merle, Philippe
Noury, Jean-Baptiste
Rouaud, Violaine
Tard, Celine
Theaudin, Marie
Vallat, Jean-Michel
Viala, Karine
Attarian, Shahram
Delmont, Emilien
CLINICAL NEUROPHYSIOLOGY, 2020, 131 (04) : 921 - 927
[7] Unique HLA haplotype associations in IgG4 anti-neurofascin 155 antibody-positive chronic inflammatory demyelinating polyneuropathy
Ogata, Hidenori
Isobe, Noriko
Zhang, Xu
Yamasaki, Ryo
Fujii, Takayuki
Machida, Akira
Morimoto, Nobutoshi
Kaida, Kenichi
Masuda, Teruaki
Ando, Yukio
Kuwahara, Motoi
Kusunoki, Susumu
Nakamura, Yuri
Matsushita, Takuya
Kira, Jun-ichi
JOURNAL OF NEUROIMMUNOLOGY, 2020, 339
[8] Paranodal lesions in chronic inflammatory demyelinating polyneuropathy associated with anti-Neurofascin 155 antibodies
Vallat, Jean-Michel
Yuki, Nobuhiro
Sekiguchi, Kenji
Kokubun, Norito
Oka, Nobuyuki
Mathis, Stephane
Magy, Laurent
Sherman, Diane L.
Brophy, Peter J.
Devaux, Jerome J.
NEUROMUSCULAR DISORDERS, 2017, 27 (03) : 290 - 293
[9] Tongue tremor in neurofascin-155 IgG4 seropositive chronic inflammatory polyradiculoneuropathy
Briani, Chiara
Salvalaggio, Alessandro
Ruiz, Marta
Cacciavillani, Mario
Rinaldi, Francesca
Callegari, Ilaria
Gasparotti, Roberto
Franciotta, Diego
JOURNAL OF NEUROIMMUNOLOGY, 2019, 330 : 178 - 180
[10] IgG4 Anti-neurofascin 155 Antibody in Peripheral and Central Demyelination
Yamasaki, Ryo
MULTIPLE SCLEROSIS JOURNAL, 2018, 24 (03) : 376 - 376

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