Objective: The application of vacuum sealing drainage (VSD) nursing technology in wounds of soft tissue defects of extremities is discussed from various aspects. It seeks a nursing method that can prevent and reduce tube blockage, restore skin tissue, increase patient comfort, reduce treatment costs, and shorten hospital stay, and provide more ideal conditions for subsequent surgical treatment. Method: Patients were selected in Tangshan Gongren Hospital from June 2016 to June 2017 as subjects. Patients admitted to the hospital are randomly divided into four groups. Channel establishment and oxygen supply group (group 1): establish a negative pressure closed drainage channel and supply a local intermittent high concentration of oxygen; channel establishment group (group 2): establish a negative pressure closed drainage channel; oxygen supply group (group 3): supply negative pressure closed drainage intermittent high concentration oxygen; control group (group 4): routine care with simple negative pressure closed drainage. The differences and effects of each group in clogging the pipeline, restoring skin tissue, increasing patient comfort, reducing treatment costs, and shortening hospital stay are analyzed. Observe the response of the subjects after each experiment. That is, the number of cases of complications such as massive bleeding, post-debridement local infection, exposed bone and tendon degeneration, necrosis, and the number of cases in which no complications occurred during the treatment. The data of this experiment are statistically described and statistically inferred by SPSS17.0 software. The chi-square test is used to compare the count data, and the variance analysis test is used to compare the measurement data. Results: by comparison, channel establishment and oxygen supply group are superior to other groups in preventing and reducing tube blockage, restoring skin tissue, increasing patient comfort, reducing treatment costs, and shortening hospital stay. Conclusion: VSD care technology may be a new approach to the treatment of soft tissue defects of extremities. it has extensive clinical application value and promotion significance.