Multivariate Statistical Analysis of Serum from Breast Cancer Patients Using Surface Enhanced Raman Spectrum

被引：7

作者：

Guo Li ^{[1
]}

Zhang Yi ^{[1
]}

Lu Jin-yan ^{[2
]}

Gao Wen-bin ^{[2
]}

Wu Shi-fa ^{[1
]}

Wang Ruo-yu ^{[2
]}

机构：

[1] Dalian Univ Technol, Inst Near Field Opt & Nanotechnol, Dalian 116024, Peoples R China

[2] Dalian Univ, Affiliated Hosp, Dalian 116001, Peoples R China

来源：

SPECTROSCOPY AND SPECTRAL ANALYSIS | 2013年 / 33卷 / 06期

关键词：

SERS; PCA; LDA; Breast cancer; Serum; SPECTROSCOPY;

D O I：

10.3964/j.issn.1000-0593(2013)06-1553-04

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

The present paper studied surface-enhanced Raman spectra (SERS) of serum from breast cancer using chemometrics methods of principal component analysis (PCA) and linear discriminant analysis (LDA) respectively. Firstly, the structure of peptidyl backbone and side chain of protein, which is destroyed in the serum from breast cancer, is explained. Meanwhile the structure of lipid and also the environment of glucid are changed. Then, we studied the SERS of 18 serum samples from breast cancer patients who were clinically diagnosed and 20 serum samples from healthy volunteers control using the method above mentioned. It was showed that the method of PCA cannot discriminate the two groups completely, but after using the method of LDA the analysis result is satisfactory.

引用

页码：1553 / 1556

页数：4

共 7 条

[1] Screening and enrichment of metal nanoparticles with novel optical properties
Emory, SR
Nie, S
[J]. JOURNAL OF PHYSICAL CHEMISTRY B, 1998, 102 (03): : 493 - 497
[2] Analysis of serum from type II diabetes mellitus and diabetic complication using surface-enhanced Raman spectra (SERS)
Han, H. W.
Yan, X. L.
Dong, R. X.
Ban, G.
Li, K.
[J]. APPLIED PHYSICS B-LASERS AND OPTICS, 2009, 94 (04): : 667 - 672
[3] Joliffe I T, 1992, Stat Methods Med Res, V1, P69, DOI 10.1177/096228029200100105
[4] Liu K., 2006, CHINESE J LIGHT SCAT, V17, P332
[5] Raman spectroscopy and multivariate analysis of serum samples from breast cancer patients
Pichardo-Molina, J. L.
Frausto-Reyes, C.
Barbosa-Garcia, O.
Huerta-Franco, R.
Gonzalez-Trujillo, J. L.
Ramirez-Alvarado, C. A.
Gutierrez-Juarez, G.
Medina-Gutierrez, C.
[J]. LASERS IN MEDICAL SCIENCE, 2007, 22 (04) : 229 - 236
[6] Xu K, 2009, CHEM J CHINESE U, V30, P1543
[7] Xu Y.M., 2005, RAMAN SPECTROSCOPY A

← 1 →