Efficient synthesis of benzothiophenes by [4+1] cycloaddition of 2-mercaptobenzaldehyde derivatives with isocyanides

被引：3
|
作者：
Soeta, Takahiro [1 ]
Shitaya, Saori [1 ]
Okuno, Takumi [1 ]
Fujinami, Shuhei [1 ]
Ukaji, Yutaka [1 ]
机构：
[1] Kanazawa Univ, Grad Sch Nat Sci & Technol, Div Mat Sci, Kanazawa, Ishikawa 9201192, Japan
来源：
TETRAHEDRON | 2016年 / 72卷 / 49期
基金：
日本学术振兴会;
关键词：
Isocyanide; 4+1] Cycloaddition; 2-Mercaptobenzaldehyde; Benzothiophene derivative; INHIBITORS; ZILEUTON; IMINES;
D O I：
10.1016/j.tet.2016.09.054
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We developed a [4+1] cycloaddition reaction of isocyanides with 2-mercaptobenzaldehydes and/or their disulfide derivatives, promoted by LiI.2H(2)O, to afford benzothiophene derivatives in moderate to good yields. Isocyanides, 2-mercaptobenzaldehydes and disulfide derivatives of various types were used successfully in the reaction. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：7901 / 7905
页数：5
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