The Russian homicide rate is among the highest in the world. Local rates are not uniform, however, but instead show tremendous variation throughout this large nation. As a result of varying levels of development, differential access to natural resources, past Soviet economic and social policies, and the varying pace of the social, political, and economic transition, there are also large differences across Russia in structural factors thought to be related to interpersonal violence. In this study, newly available vital statistics and socioeconomic data were employed to estimate the effects of social structural characteristics on homicide rates in the Russian regions (n = 78). Results revealed that commonly tested covariates such as poverty and single-parent households were positively associated with regional homicide victimization rates, as was a proxy for heavy drinking. Further, homicide rates in the Northern Caucasus and the regions east of the Ural mountains are significantly lower and higher, respectively, than in the rest of the country. These results are discussed in terms of the current Russian situation and integrated into the broader literature on social structure and homicide. (c) 2005 Elsevier Inc. All rights reserved.