The effect of several antipyretic analgesics on mitomycin C-induced mutagenesis using the wing spot test in Drosophila melanogaster

被引：0
|
作者：
Sato, T
Nagaoka, K
Nagase, H
Niikawa, M
Kito, H
机构：
来源：
JAPANESE JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH | 1996年 / 42卷 / 02期
关键词：
antimutagenicity; bio-antimutagenicity; chromosome recombination; antipyretic analgesic; wing spot test; Drosophila melanogaster;
D O I：
暂无
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
The effect of several antipyretic analgesics on mitomycin C-induced mutagenesis was investigated using the wing spot test in Drosophila melanogaster. Aspirin, ibuprofen and indomethacin showed strong antimutagenicity, while the antimutagenicity of acetaminophen and ethenzamide were weaker. Aspirin inhibited chromosome recombination. A considerable part of the antimutagenicity of aspirin, ibuprofen and indomethacin can be explained by bio-antimutagenicity.
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页码：136 / 141
页数：6
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