A Fast Process for Imprinting Micro and Nano Patterns on Electrospun Fiber Meshes at Physiological Temperatures

被引:44
|
作者
Nandakumar, Anandkumar [1 ]
Truckenmuller, Roman [1 ]
Ahmed, Maqsood [1 ]
Damanik, Febriyani [1 ]
Reis Santos, Diogo [2 ]
Auffermann, Nils [1 ]
de Boer, Jan [1 ]
Habibovic, Pamela [1 ]
van Blitterswijk, Clemens [1 ]
Moroni, Lorenzo [1 ]
机构
[1] Univ Twente, Dept Tissue Regenerat, MIRA Inst Biomed Technol & Tech Med, NL-7500 AE Enschede, Netherlands
[2] Univ Catolica Portuguesa, Escola Super Biotecnol, P-4200072 Porto, Portugal
关键词
electrospinning; patterning; physiological temperatures; biomedical engineering; fibers; MESENCHYMAL STEM-CELLS; SCAFFOLDS; DIFFERENTIATION; BIOMATERIALS; EXPRESSION; SURFACES; GROWTH;
D O I
10.1002/smll.201300220
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Electrospun fiber meshes are patterned at length scales comparable to or lower than their fiber diameter. Simple nano- and microgrooves and closed geometric shapes are imprinted in different tones using a fast imprint process at physiological temperatures. Human mesenchymal stromal cells cultured on patterned scaffolds show differences in cellular morphology and cytoskeleton organization. Microgrooved electrospun fibers support upregulation of alkaline phosphatase and bone morphogenetic protein-2 gene expression when cells are cultured in osteogenic medium. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码:3405 / 3409
页数:5
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