Esophageal disease among childhood cancer survivors-A report from the Childhood Cancer Survivors Study

被引：1

作者：

Asdahl, Peter H. ^{[1
]}

Oeffinger, Kevin C. ^{[2
]}

Albieri, Vanna ^{[3
]}

Hudson, Melissa ^{[4
]}

Leisenring, Wendy M. ^{[5
]}

Donaldson, Sarah S. ^{[6
]}

Hasle, Henrik ^{[7
]}

Winther, Jeanette F. ^{[8
,9
]}

Armstrong, Gregory T. ^{[10
]}

Robison, Leslie L. ^{[10
]}

机构：

[1] Aarhus Univ Hosp, Dept Hematol Oeffinger, Aarhus, Denmark

[2] Duke Canc Inst, Dept Med, Durham, NC USA

[3] Danish Canc Soc, Res Ctr, Unit Stat & Data Anal, Copenhagen, Denmark

[4] St Jude Childrens Res Hosp, Dept Oncol & Epidemiol, 332 N Lauderdale St, Memphis, TN 38105 USA

[5] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA

[6] Stanford Univ, Dept Radiat Oncol, Stanford, CA 94305 USA

[7] Aarhus Univ Hosp, Dept Pediat, Aarhus, Denmark

[8] Danish Canc Soc, Childhood Canc Res Grp, Res Ctr, Copenhagen, Denmark

[9] Aarhus Univ Hosp, Dept Clin Med, Aarhus, Denmark

[10] St Jude Childrens Res Hosp, Dept Epidemiol & Canc Control, 332 N Lauderdale St, Memphis, TN 38105 USA

来源：

PEDIATRIC BLOOD & CANCER | 2021年 / 68卷 / 08期

关键词：

chemotherapy; childhood cancer survivorship; esophageal disease; esophageal stricture; radiation;

D O I：

10.1002/pbc.29043

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

There is limited information addressing the occurrence of esophageal strictures among the growing population of survivors of childhood cancer. Using the Childhood Cancer Survivor Study, we analyzed data from 17,121 5-year survivors and 3400 siblings to determine the prevalence and risk factors for esophageal strictures. Prevalence among survivors was 2.0% (95% confidence interval [CI]: 1.8-2.2%), representing a 7.6-fold increased risk compared to siblings. Factors significantly associated with risk of esophageal stricture included diagnosis of Hodgkin lymphoma, greater chest radiation dose, younger age at cancer diagnosis, platinum chemotherapy, and hematopoietic stem cell transplantation. While uncommon, survivors are at risk for therapy-related esophageal strictures.

引用

页数：5

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