Scalable electrochemical reduction of sulfoxides to sulfides

被引：34
|
作者：
Kong, Zhenshuo [1 ]
Pan, Chao [1 ]
Li, Ming [1 ]
Wen, Lirong [1 ]
Guo, Weisi [1 ]
机构：
[1] Qingdao Univ Sci & Technol, Coll Chem & Mol Engn, State Key Lab Base Ecochem Engn, Qingdao 266042, Peoples R China
来源：
GREEN CHEMISTRY | 2021年 / 23卷 / 07期
基金：
中国国家自然科学基金;
关键词：
D O I：
10.1039/d1gc00591j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A scalable reduction of sulfoxides to sulfides in a sustainable way remains an unmet challenge. This report discloses an electrochemical reduction of sulfoxides on a large scale (>10 g) under mild reaction conditions. Sulfoxides are activated using a substoichiometric amount of the Lewis acid AlCl3, which could be regenerated via a combination of inexpensive aluminum anode with chloride anion. This deoxygenation process features a broad substrate scope, including acid-labile substrates and drug molecules.
引用
收藏
页码：2773 / 2777
页数：5
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